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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL3670650
Molecular formula	C27H28F2N4O5
IUPAC name	[5-[4-(difluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]-[3-[2-methoxy-4-(2-oxa-5-azaspiro[3.4]octan-5-ylmethyl)phenoxy]azetidin-1-yl]methanone
Molecular weight	526.541
Hydrogen bond acceptor	10
Hydrogen bond donor	0
XlogP	3.1
Synonyms	US8685958, 18 AOUVKOSBHGGHLV-UHFFFAOYSA-N (3-(4-(2-oxa-5-azaspiro[3.4]octan-5-ylmethyl)-2-methoxyphenoxy)azetidin-1-yl)(5-(4-(difluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)methanone BDBM119769 SCHEMBL14638220
Inchi Key	AOUVKOSBHGGHLV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H28F2N4O5/c1-35-22-11-17(12-33-10-2-9-27(33)15-36-16-27)3-8-21(22)37-20-13-32(14-20)26(34)25-31-30-24(38-25)19-6-4-18(5-7-19)23(28)29/h3-8,11,20,23H,2,9-10,12-16H2,1H3
PubChem CID	71227171
ChEMBL	CHEMBL3670650
IUPHAR	N/A
BindingDB	119769
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	150.0 nM	, None	BindingDB,ChEMBL

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