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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL367530
Molecular formulaC29H28N6O3
IUPAC name1-N,1-N,4-N,4-N-tetramethyl-3-[4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]indole-1,4-dicarboxamide
Molecular weight508.582
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP3.1
SynonymsBDBM50062122
SCHEMBL7490491
3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzoyl]-indole-1,4-dicarboxylic acid bis-dimethylamide
Inchi KeyGTOLUNAZLSXFSR-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H28N6O3/c1-18-31-23-15-30-14-13-24(23)34(18)16-19-9-11-20(12-10-19)27(36)22-17-35(29(38)33(4)5)25-8-6-7-21(26(22)25)28(37)32(2)3/h6-15,17H,16H2,1-5H3
PubChem CID10505821
ChEMBLCHEMBL367530
IUPHARN/A
BindingDB50062122
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki11.0 nMPMID9438024BindingDB,ChEMBL

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