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Name | D(1A) dopamine receptor |
---|---|
Species | Sus scrofa (Pig) |
Gene | DRD1 |
Synonym | Dopamine D1 receptor |
Disease | N/A for non-human GPCRs |
Length | 446 |
Amino acid sequence | MRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLGKTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT |
UniProt | P50130 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5067 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL378515 |
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Molecular formula | C18H20ClN5O |
IUPAC name | 6-chloro-2-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]imidazo[1,2-b]pyridazine |
Molecular weight | 357.842 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 2.7 |
Synonyms | BDBM50189840 6-chloro-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-b]pyridazine |
Inchi Key | GSYFEKZSWFXBAB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H20ClN5O/c1-25-16-5-3-2-4-15(16)23-10-8-22(9-11-23)12-14-13-24-18(20-14)7-6-17(19)21-24/h2-7,13H,8-12H2,1H3 |
PubChem CID | 11581237 |
ChEMBL | CHEMBL378515 |
IUPHAR | N/A |
BindingDB | 50189840 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 7700.0 nM | PMID16789750 | BindingDB,ChEMBL |
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