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GPCR

NameType-1 angiotensin II receptor
SpeciesCavia porcellus (Guinea pig)
GeneAGTR1
SynonymAngiotensin II type-1 receptor
AT1
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
UniProtQ9WV26
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1671613
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL341223
Molecular formulaC25H21N5O
IUPAC name2-methyl-4-[1-[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]ethoxy]quinoline
Molecular weight407.477
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.3
Synonyms2-Methyl-4-[1-[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]ethoxy]quinoline
BDBM50003394
L005983
2-Methyl-4-{1-[2''-(1H-tetrazol-5-yl)-biphenyl-4-yl]-ethoxy}-quinoline
SCHEMBL9315620
Inchi KeyGSBQRUQGRWSSFO-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H21N5O/c1-16-15-24(22-9-5-6-10-23(22)26-16)31-17(2)18-11-13-19(14-12-18)20-7-3-4-8-21(20)25-27-29-30-28-25/h3-15,17H,1-2H3,(H,27,28,29,30)
PubChem CID9909335
ChEMBLCHEMBL341223
IUPHARN/A
BindingDB50003394
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5040.0 nMPMID1433210BindingDB,ChEMBL

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