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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	.delta.-Yohimbine
Molecular formula	C21H24N2O3
IUPAC name	methyl 16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate
Molecular weight	352.434
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.7
Synonyms	CHEMBL1604074 I06-0408 Methyl 19-methyl-16,17-didehydrooxayohimban-16-carboxylate # NSC-95087 Raubaserp SR-01000625463-4 VU0002262-1 6474-90-4 Alkaloid F GRTOGORTSDXSFK-UHFFFAOYSA-N Lamuran MolPort-001-918-389 NSC95087 Raumalina Substance II (-)-Tetrahydroalstonine AC1Q5YMQ Alstonine,4,5,6-tetrahydro-, (3.alpha.)- BDBM30993 HMS2271A14 methyl 19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate NSC-72115 Oxayohimban-16-carboxylic acid,17-didehydro-19-methyl-, methyl ester, (19.alpha.,20.alpha.)- SMR000107477 Vincein 16,17-Didehydro-19.alpha.-methyloxayohimban-16-carboxylic acid methyl ester AKOS021983176 cid_251561 Isoarteril MLS000111555 NSC72115 Raubasil ST50219455 WLN: T F6 D5 C666 EM ON SO TU&&TTTJ R1 UVO1 876659-81-3 Alkaloid II H3160 MCULE-3271406637 NCI60_041492 Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19.alpha.)- Rauvasan Tensyl ACN-056788 BAS 00225301 CCG-103005 Hydrosarpan Methyl 19-methyl-16,17-didehydrooxayohimban-16-carboxylate NSC-72133 Ranitol SR-01000625463 Vinceine Alkaloid C D01JGV L001109 MLS002540766 NSC72133 Raubasin STK367072 (-)-Ajmalicin AC1L5K45 Alstonine,4,5,6-tetrahydro- HMS1607K01 methyl 1-methyl-5,11,14,14a,4a,5a-hexahydro-1H-indolo[2,3-a]pyrano[3,4-g]quino lizine-4-carboxylate NCI60_041515 Oxayohimban-16-carboxylic acid,17-didehydro-19-methyl-, methyl ester, (19.alpha.)- SCHEMBL309915 Vincain AKOS000730693 BBL005709 [ Show all ]
Inchi Key	GRTOGORTSDXSFK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3
PubChem CID	251561
ChEMBL	N/A
IUPHAR	N/A
BindingDB	30993
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5.0 nM	PMID1353247	PDSP,BindingDB

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