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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL384116
Molecular formula	C33H35Cl4N3O
IUPAC name	2-[1-(1-cyclopentylpiperidin-4-yl)-6-(2,5-dichlorophenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3,5-dichlorophenyl)acetamide
Molecular weight	631.463
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	8.9
Synonyms	BDBM50190894 SCHEMBL13918017 2-(1-(1-cyclopentylpiperidin-4-yl)-6-(2,5-dichlorophenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,5-dichlorophenyl)acetamide
Inchi Key	AOGVTUDRZQZUJZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C33H35Cl4N3O/c34-24-6-8-31(37)30(19-24)22-5-7-29-23(15-22)11-14-40(20-32(41)38-27-17-25(35)16-26(36)18-27)33(29)21-9-12-39(13-10-21)28-3-1-2-4-28/h5-8,15-19,21,28,33H,1-4,9-14,20H2,(H,38,41)
PubChem CID	44416173
ChEMBL	CHEMBL384116
IUPHAR	N/A
BindingDB	50190894
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	87.0 nM	PMID16824753	BindingDB,ChEMBL

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