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GPCR

NameNeuropeptide Y receptor type 5
SpeciesHomo sapiens (Human)
GeneNPY5R
SynonymNPYY5-R
NPY5-R
NPY-Y5 receptor
neuropeptide Y receptor type 5
food intake receptor
[ Show all ]
DiseaseEating disorder; Obesity
Eating disorder; Obesity; Diabetes
Major depressive disorder
Obesity
Length445
Amino acid sequenceMDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProtQ15761
Protein Data BankN/A
GPCR-HGmod modelQ15761
3D structure modelThis predicted structure model is from GPCR-EXP Q15761.
BioLiPN/A
Therapeutic Target DatabaseT20331
ChEMBLCHEMBL4561
IUPHAR308
DrugBankN/A

Ligand

NameCHEMBL6938
Molecular formulaC19H18N2O
IUPAC name13-methoxy-4-phenyl-3,5-diazatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),3,11,13-pentaene
Molecular weight290.366
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.0
Synonyms9-Methoxy-2-phenyl-3,4,5,6-tetrahydro-1,3-diaza-benzo[e]azulene
2-Phenyl-9-methoxy-3,4,5,6-tetrahydrobenzo[3,4]cyclohepta[1,2-d]imidazole
BDBM50111096
SCHEMBL6836945
Inchi KeyAOBJTWDVQLXNDW-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H18N2O/c1-22-15-11-10-13-8-5-9-17-18(16(13)12-15)21-19(20-17)14-6-3-2-4-7-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,20,21)
PubChem CID22934130
ChEMBLCHEMBL6938
IUPHARN/A
BindingDB50111096
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5025.0 nMPMID11909705ChEMBL
IC5025.0 nMPMID11909705BindingDB

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