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GPCR

NameType-1 angiotensin II receptor
SpeciesOryctolagus cuniculus (Rabbit)
GeneAGTR1
SynonymAngiotensin II type-1 receptor
AT1
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
UniProtP34976
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3948
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL155599
Molecular formulaC24H21BrClN3O4
IUPAC name3-[[3-bromo-2-(2-carbamoylphenyl)-1-benzofuran-5-yl]methyl]-2-butyl-5-chloroimidazole-4-carboxylic acid
Molecular weight530.803
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.8
SynonymsN/A
Inchi KeyANZBBDGMWLXNHM-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H21BrClN3O4/c1-2-3-8-18-28-22(26)20(24(31)32)29(18)12-13-9-10-17-16(11-13)19(25)21(33-17)14-6-4-5-7-15(14)23(27)30/h4-7,9-11H,2-3,8,12H2,1H3,(H2,27,30)(H,31,32)
PubChem CID44370385
ChEMBLCHEMBL155599
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
pKB7.2 -Bioorg. Med. Chem. Lett., (1993) 3:4:589ChEMBL

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