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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	BAS 03421985
Molecular formula	C18H14N6O3
IUPAC name	1-methyl-4-nitro-N-(2-phenyl-3H-benzimidazol-5-yl)pyrazole-3-carboxamide
Molecular weight	362.349
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.5
Synonyms	ZINC6445037 1-methyl-4-nitro-N-(2-phenyl-1H-benzimidazol-5-yl)pyrazole-3-carboxamide MCULE-7001650455 AKOS000636667 Oprea1_833558 CHEMBL1527551 1-methyl-4-nitro-N-(2-phenyl-3H-benzimidazol-5-yl)pyrazole-3-carboxamide MLS000561332 SMR000178027 1-Methyl-4-nitro-1H-pyrazole-3-carboxylic acid (2-phenyl-1H-benzoimidazol-5-yl)-amide HMS2510K18 AC1MK1FU Oprea1_447631 [ Show all ]
Inchi Key	AAABHMIRDIOYOK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H14N6O3/c1-23-10-15(24(26)27)16(22-23)18(25)19-12-7-8-13-14(9-12)21-17(20-13)11-5-3-2-4-6-11/h2-10H,1H3,(H,19,25)(H,20,21)
PubChem CID	3147229
ChEMBL	CHEMBL1527551
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	11220.2 nM	PubChem BioAssay data set	ChEMBL

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