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BioLiP Library
Download all results in tab-seperated text for 782 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1ap9:A (2.35) BS01 RET ? GO:0005216 ... P02945 9287223
    2 1at9:A (2.8) BS01 RET ? GO:0005216 ... P02945 9296502
    3 1bm1:A (3.5) BS01 RET ? GO:0005216 ... P02945 10393291
    4 1brd:A (3.5) BS01 RET ? GO:0005216 ... P02945 2359127
    5 1brr:A (2.9) BS02 RET ? GO:0005216 ... P02945 9751724
    6 1brr:B (2.9) BS02 RET ? GO:0005216 ... P02945 9751724
    7 1brr:C (2.9) BS04 RET ? GO:0005216 ... P02945 9751724
    8 1brx:A (2.3) BS01 RET ? GO:0005216 ... P02945 9632391
    9 1c3w:A (1.55) BS01 RET ? GO:0005216 ... P02945 10452895
    10 1c8r:A (1.8) BS01 RET ? GO:0005216 ... P02945 10514362
    11 1c8s:A (2.0) BS01 RET ? GO:0005216 ... P02945 10514362
    12 1cwq:A (2.25) BS01 RET ? GO:0005216 ... P02945 10949308
    13 1cwq:A (2.25) BS02 RET ? GO:0005216 ... P02945 10949308
    14 1cwq:B (2.25) BS01 RET ? GO:0005216 ... P02945 10949308
    15 1cwq:B (2.25) BS02 RET ? GO:0005216 ... P02945 10949308
    16 1dze:A (2.5) BS02 RET ? GO:0005216 ... P02945 15328615
    17 1e0p:A (2.1) BS01 RET ? GO:0005216 ... P02945 10949307
    18 1e12:A (1.8) BS03 RET ? GO:0005216 ... P0DMH7 10827943
    19 1f4z:A (1.8) BS01 RET ? GO:0005216 ... P02945 10903866
    20 1f50:A (1.7) BS01 RET ? GO:0005216 ... P02945 10903866
    21 1f88:A (2.8) BS02 RET ? GO:0000139 ... P02699 10926528
    22 1f88:B (2.8) BS01 RET ? GO:0000139 ... P02699 10926528
    23 1fbb:A (3.2) BS01 RET ? GO:0005216 ... P02945 10949309
    24 1fbk:A (3.2) BS01 RET ? GO:0005216 ... P02945 10949309
    25 1gu8:A (2.27) BS01 RET ? GO:0005216 ... P42196 11937052
    26 1gue:A (2.27) BS01 RET ? GO:0005216 ... P42196 11937052
    27 1gzm:A (2.65) BS01 RET ? GO:0000139 ... P02699 15491621
    28 1gzm:B (2.65) BS01 RET ? GO:0000139 ... P02699 15491621
    29 1h2s:A (1.93) BS01 RET ? GO:0005216 ... P42196 12368857
    30 1h68:A (2.1) BS01 RET ? GO:0005216 ... P42196 11504917
    31 1hzx:A (2.8) BS04 RET ? GO:0000139 ... P02699 11425302
    32 1hzx:B (2.8) BS03 RET ? GO:0000139 ... P02699 11425302
    33 1iw6:A (2.3) BS01 RET ? GO:0005216 ... P02945 12445782
    34 1iw9:A (2.5) BS01 RET ? GO:0005216 ... P02945 15328615
    35 1ixf:A (2.6) BS01 RET ? GO:0005216 ... P02945 12445782
    36 1jfp:A (-1.00) BS01 RET ? GO:0000139 ... P02699 11570894
    37 1jgj:A (2.4) BS01 RET ? GO:0005216 ... P42196 11452084
    38 1jv6:A (2.0) BS01 RET ? GO:0005886 ... P02945 11676543
    39 1jv7:A (2.25) BS01 RET ? GO:0005216 ... P02945 11676543
    40 1kg8:A (2.0) BS01 RET ? GO:0005216 ... P02945 11721006
    41 1kg9:A (1.81) BS01 RET ? GO:0005216 ... P02945 11721006
    42 1kgb:A (1.65) BS01 RET ? GO:0005216 ... P02945 11721006
    43 1kme:A (2.0) BS01 RET ? GO:0005216 ... P02945 11829498
    44 1kme:B (2.0) BS02 RET ? GO:0005216 ... P02945 11829498
    45 1l9h:A (2.6) BS04 RET ? GO:0000139 ... P02699 11972040
    46 1l9h:B (2.6) BS04 RET ? GO:0000139 ... P02699 11972040
    47 1ln6:A (-1.00) BS01 RET ? GO:0000139 ... P02699 12044163
    48 1m0k:A (1.43) BS01 RET ? GO:0005216 ... P02945 12206785
    49 1m0l:A (1.47) BS01 RET ? GO:0005216 ... P02945 12206785
    50 1m0m:A (1.43) BS01 RET ? GO:0005216 ... P02945 12206786
    51 1mgy:A (2.0) BS03 RET ? GO:0005216 ... P02945 12829500
    52 1o0a:A (1.62) BS01 RET ? GO:0005216 ... P02945 12691752
    53 1opb:A (1.9) BS01 RET ? GO:0005504 ... P06768 8487303 MOAD: Kd=50nM
    54 1opb:B (1.9) BS01 RET ? GO:0005504 ... P06768 8487303 MOAD: Kd=50nM
    55 1opb:C (1.9) BS01 RET ? GO:0005504 ... P06768 8487303 MOAD: Kd=50nM
    56 1opb:D (1.9) BS01 RET ? GO:0005504 ... P06768 8487303 MOAD: Kd=50nM
    57 1p8h:A (1.52) BS01 RET ? GO:0005216 ... P02945 12842471
    58 1p8i:A (1.86) BS01 RET ? GO:0005216 ... P02945 12842471
    59 1p8u:A (1.62) BS01 RET ? GO:0005216 ... P02945 12842471
    60 1pxr:A (1.7) BS01 RET ? GO:0005216 ... P02945 14659758
    61 1pxr:B (1.7) BS01 RET ? GO:0005216 ... P02945 14659758
    62 1pxs:A (2.2) BS01 RET ? GO:0005216 ... P02945 14659758
    63 1pxs:B (2.2) BS01 RET ? GO:0005216 ... P02945 14659758
    64 1py6:A (1.8) BS01 RET ? GO:0005216 ... P02945 14659758
    65 1py6:B (1.8) BS01 RET ? GO:0005216 ... P02945 14659758
    66 1q5i:A (2.3) BS01 RET ? GO:0005216 ... P02945 14732697
    67 1q5i:B (2.3) BS01 RET ? GO:0005216 ... P02945 14732697
    68 1q5j:A (2.1) BS01 RET ? GO:0005216 ... P02945 14732697
    69 1q5j:B (2.1) BS01 RET ? GO:0005216 ... P02945 14732697
    70 1qhj:A (1.9) BS01 RET ? GO:0005216 ... P02945 10467143
    71 1qko:A (2.1) BS01 RET ? GO:0005216 ... P02945 10548112
    72 1qkp:A (2.1) BS01 RET ? GO:0005216 ... P02945 10548112
    73 1qm8:A (2.5) BS01 RET ? GO:0005216 ... P02945 9769218
    74 1r2n:A (-1.00) BS01 RET ? GO:0005216 ... P02945 12119389
    75 1r84:A (-1.00) BS01 RET ? GO:0005216 ... P02945 12119389
    76 1s51:A (2.0) BS01 RET ? GO:0005216 ... P02945 14982414
    77 1s51:B (2.0) BS01 RET ? GO:0005216 ... P02945 14982414
    78 1s52:A (2.3) BS01 RET ? GO:0005216 ... P02945 14982414
    79 1s52:B (2.3) BS01 RET ? GO:0005216 ... P02945 14982414
    80 1s53:A (2.0) BS01 RET ? GO:0005216 ... P02945 14982414
    81 1s53:B (2.0) BS01 RET ? GO:0005216 ... P02945 14982414
    82 1s54:A (2.2) BS01 RET ? GO:0005216 ... P02945 14982414
    83 1s54:B (2.2) BS01 RET ? GO:0005216 ... P02945 14982414
    84 1s8j:A (2.3) BS02 RET ? GO:0005216 ... P02945 15109251
    85 1s8l:A (2.3) BS01 RET ? GO:0005216 ... P02945 15109251
    86 1tn0:A (2.5) BS01 RET ? GO:0005216 ... P02945 15312757
    87 1tn0:B (2.5) BS01 RET ? GO:0005216 ... P02945 15312757
    88 1tn5:A (2.2) BS01 RET ? GO:0005216 ... P02945 15312757
    89 1tn5:B (2.2) BS01 RET ? GO:0005216 ... P02945 15312757
    90 1u19:A (2.2) BS05 RET ? GO:0000139 ... P02699 15327956
    91 1u19:B (2.2) BS04 RET ? GO:0000139 ... P02699 15327956
    92 1uaz:A (3.4) BS01 RET ? GO:0005216 ... P69051 N/A
    93 1uaz:B (3.4) BS01 RET ? GO:0005216 ... P69051 N/A
    94 1ucq:A (2.4) BS01 RET ? GO:0005216 ... P02945 14672661
    95 1vgo:A (2.5) BS01 RET ? GO:0005216 ... P29563 16540121
    96 1vgo:B (2.5) BS01 RET ? GO:0005216 ... P29563 16540121
    97 1vjm:A (2.3) BS01 RET ? GO:0005216 ... P02945 14532280
    98 1x0i:1 (2.3) BS02 RET ? GO:0005216 ... P02945 16023672
    99 1x0k:1 (2.6) BS01 RET ? GO:0005216 ... P02945 16023672
    100 1x0s:A (2.5) BS01 RET ? GO:0005216 ... P02945 16084526
    101 1xio:A (2.0) BS01 RET ? GO:0005216 ... Q8YSC4 15459346
    102 1xji:A (2.2) BS01 RET ? GO:0005216 ... P02945 15689517
    103 2at9:A (3.0) BS01 RET ? GO:0005216 ... P02945 10024456
    104 2brd:A (3.5) BS01 RET ? GO:0005216 ... P02945 8676377
    105 2ei4:A (2.1) BS01 RET ? GO:0005216 ... P29563 18082767
    106 2f93:A (2.0) BS01 RET ? GO:0005216 ... P42196 16452929
    107 2f95:A (2.2) BS01 RET ? GO:0005216 ... P42196 16452929
    108 2g79:A (1.69) BS01 RET ? GO:0001972 ... P29373 17447762 MOAD: Kd=120nM
    PDBbind: -logKd/Ki=6.92, Kd=120nM
    109 2g87:A (2.6) BS05 RET ? GO:0000139 ... P02699 16586416
    110 2g87:B (2.6) BS04 RET ? GO:0000139 ... P02699 16586416
    111 2hpy:A (2.8) BS04 RET ? GO:0000139 ... P02699 16908857
    112 2hpy:B (2.8) BS04 RET ? GO:0000139 ... P02699 16908857
    113 2i1x:A (2.0) BS01 RET ? GO:0005216 ... P02945 17002299
    114 2i20:A (2.08) BS01 RET ? GO:0005216 ... P02945 17002299
    115 2i21:A (1.84) BS01 RET ? GO:0005216 ... P02945 17002299
    116 2i35:A (3.8) BS01 RET ? GO:0000139 ... P02699 17060607
    117 2j4y:A (3.4) BS01 RET ? GO:0000139 ... P02699 17825322
    118 2j4y:B (3.4) BS01 RET ? GO:0000139 ... P02699 17825322
    119 2j4y:B (3.4) BS02 RET ? GO:0000139 ... P02699 17825322
    120 2jaf:A (1.7) BS03 RET ? GO:0005216 ... B0R2U4 17117890
    121 2jag:A (1.93) BS03 RET ? GO:0005216 ... B0R2U4 17117890
    122 2ksy:A (-1.00) BS01 RET N/A GO:0005216 ... N/A 20512150
    123 2l6x:A (-1.00) BS01 RET ? GO:0005216 ... Q9F7P4 22034093
    124 2m3g:A (-1.00) BS01 RET ? GO:0005216 ... Q8YSC4 24013819
    125 2m3g:B (-1.00) BS01 RET ? GO:0005216 ... Q8YSC4 24013819
    126 2m3g:C (-1.00) BS01 RET ? GO:0005216 ... Q8YSC4 24013819
    127 2ntu:A (1.53) BS01 RET ? GO:0005216 ... P02945 17141271
    128 2ntw:A (1.53) BS01 RET ? GO:0005216 ... P02945 17141271
    129 2ped:A (2.95) BS05 RET ? GO:0000139 ... P02699 17449675
    130 2ped:B (2.95) BS04 RET ? GO:0000139 ... P02699 17449675
    131 2wjk:A (2.3) BS01 RET ? GO:0005216 ... P02945 20680951
    132 2wjl:A (2.15) BS01 RET ? GO:0005216 ... P02945 20680951
    133 2x72:A (3.0) BS02 RET ? GO:0000139 ... P02699 21389983
    134 2z55:A (2.5) BS01 RET ? GO:0005216 ... P29563 18082767
    135 2z55:B (2.5) BS02 RET ? GO:0005216 ... P29563 18082767
    136 2z55:D (2.5) BS03 RET ? GO:0005216 ... P29563 18082767
    137 2z55:E (2.5) BS02 RET ? GO:0005216 ... P29563 18082767
    138 2z73:A (2.5) BS01 RET ? GO:0004930 ... P31356 18480818
    139 2z73:B (2.5) BS01 RET ? GO:0004930 ... P31356 18480818
    140 2zfe:A (2.5) BS01 RET ? GO:0005216 ... P02945 18930734
    141 2ziy:A (3.7) BS01 RET ? GO:0004930 ... P31356 18463093
    142 2zzl:A (2.03) BS02 RET ? GO:0005216 ... P02945 19712684
    143 3a7k:A (2.0) BS01 RET N/A GO:0005216 ... N/A 19961859
    144 3a7k:B (2.0) BS02 RET N/A GO:0005216 ... N/A 19961859
    145 3a7k:D (2.0) BS03 RET N/A GO:0005216 ... N/A 19961859
    146 3abw:A (1.9) BS01 RET N/A GO:0005216 ... N/A N/A
    147 3abw:B (1.9) BS01 RET N/A GO:0005216 ... N/A N/A
    148 3abw:D (1.9) BS02 RET N/A GO:0005216 ... N/A N/A
    149 3am6:A (3.2) BS01 RET ? GO:0005216 ... G1K3Q0 21726566
    150 3am6:B (3.2) BS01 RET ? GO:0005216 ... G1K3Q0 21726566
    151 3am6:C (3.2) BS01 RET ? GO:0005216 ... G1K3Q0 21726566
    152 3am6:D (3.2) BS01 RET ? GO:0005216 ... G1K3Q0 21726566
    153 3aym:A (2.8) BS01 RET ? GO:0004930 ... P31356 21906602
    154 3aym:B (2.8) BS01 RET ? GO:0004930 ... P31356 21906602
    155 3ayn:A (2.7) BS01 RET ? GO:0004930 ... P31356 21906602
    156 3ayn:B (2.7) BS01 RET ? GO:0004930 ... P31356 21906602
    157 3c9l:A (2.646) BS02 RET ? GO:0000139 ... P02699 18645239
    158 3c9m:A (3.4) BS01 RET ? GO:0000139 ... P02699 18645239
    159 3coc:A (2.31) BS01 RET ? GO:0005216 ... P02945 18500332
    160 3coc:B (2.31) BS01 RET ? GO:0005216 ... P02945 18500332
    161 3cod:A (2.7) BS01 RET ? GO:0005216 ... P02945 18500332
    162 3cod:B (2.7) BS01 RET ? GO:0005216 ... P02945 18500332
    163 3ddl:A (1.9) BS02 RET ? GO:0006811 ... Q2S2F8 18922772
    164 3ddl:B (1.9) BS02 RET ? GO:0006811 ... Q2S2F8 18922772
    165 3han:A (2.75) BS01 RET ? GO:0005216 ... P02945 19603754
    166 3hao:A (2.49) BS01 RET ? GO:0005216 ... P02945 19603754
    167 3hao:B (2.49) BS01 RET ? GO:0005216 ... P02945 19603754
    168 3hap:A (1.6) BS01 RET ? GO:0005216 ... P02945 19603754
    169 3haq:A (2.3) BS01 RET ? GO:0005216 ... P02945 19603754
    170 3har:A (1.7) BS01 RET ? GO:0005216 ... P02945 19603754
    171 3has:A (1.9) BS01 RET ? GO:0005216 ... P02945 19603754
    172 3hx3:A (1.69) BS01 RET ? GO:0005502 ... P12271 19846785 MOAD: Kd~10nM
    PDBbind: -logKd/Ki=8.00, Kd=10nM
    173 3hy5:A (3.04) BS01 RET ? GO:0005502 ... P12271 19846785 PDBbind: -logKd/Ki=7.70, Kd=20nM
    174 3mbv:A (2.0) BS01 RET ? GO:0005216 ... P02945 N/A
    175 3ns0:A (1.78) BS01 RET ? GO:0005216 ... P02945 21530535
    176 3nsb:A (1.78) BS01 RET ? GO:0005216 ... P02945 21530535
    177 3oax:A (2.6) BS01 RET ? GO:0000139 ... P02699 20923672
    178 3oax:B (2.6) BS01 RET ? GO:0000139 ... P02699 20923672
    179 3pqr:A (2.85) BS04 RET ? GO:0000139 ... P02699 21389988
    180 3pxo:A (3.0) BS01 RET ? GO:0000139 ... P02699 21389988
    181 3qap:A (1.9) BS01 RET ? GO:0005216 ... P42196 21840321
    182 3qbg:A (1.8) BS01 RET ? GO:0005216 ... P15647 21871461
    183 3qbg:B (1.8) BS01 RET ? GO:0005216 ... P15647 21871461
    184 3qbg:D (1.8) BS01 RET ? GO:0005216 ... P15647 21871461
    185 3qbi:A (2.1) BS01 RET ? GO:0005216 ... P15647 21871461
    186 3qbi:B (2.1) BS01 RET ? GO:0005216 ... P15647 21871461
    187 3qbi:D (2.1) BS01 RET ? GO:0005216 ... P15647 21871461
    188 3qbk:A (2.2) BS01 RET ? GO:0005216 ... P15647 21871461
    189 3qbk:B (2.2) BS01 RET ? GO:0005216 ... P15647 21871461
    190 3qbk:D (2.2) BS02 RET ? GO:0005216 ... P15647 21871461
    191 3qbl:A (2.2) BS01 RET ? GO:0005216 ... P15647 N/A
    192 3qbl:B (2.2) BS01 RET ? GO:0005216 ... P15647 N/A
    193 3qbl:D (2.2) BS01 RET ? GO:0005216 ... P15647 N/A
    194 3qdc:A (2.5) BS01 RET ? GO:0005216 ... P42196 21840321
    195 3t45:A (3.01) BS01 RET ? GO:0005216 ... P02945 22123198
    196 3t45:B (3.01) BS01 RET ? GO:0005216 ... P02945 22123198
    197 3t45:C (3.01) BS01 RET ? GO:0005216 ... P02945 22123198
    198 3ug9:A (2.3) BS01 RET ? GO:0016020 ... Q8RUT8
    Q93WP2    		 22266941
    199 3utv:A (2.06) BS01 RET ? GO:0005216 ... P02945 22566663
    200 3utw:A (2.4) BS01 RET ? GO:0005216 ... P02945 22566663
    Reference:
    • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
    • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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