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BioLiP Library
Download all results in tab-seperated text for 17 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1rkp:A (2.05) BS02 IBM 3.1.4.35 GO:0004114 ... O76074 14668322 BindingDB: Ki=8500nM, IC50=2100nM
    2 1zkl:A (1.67) BS02 IBM 3.1.4.53 GO:0004114 ... Q13946 15994308 MOAD: ic50=8.1uM
    PDBbind: -logKd/Ki=5.09, IC50=8.1uM
    BindingDB: IC50=85600nM, Ki=4000nM
    3 1zkn:A (2.1) BS02 IBM 3.1.4.53 GO:0004114 ... Q08499 14668322 PDBbind: -logKd/Ki=4.51, IC50=31uM
    BindingDB: IC50=31000nM
    4 1zkn:B (2.1) BS02 IBM 3.1.4.53 GO:0004114 ... Q08499 14668322 BindingDB: IC50=31000nM
    5 1zkn:C (2.1) BS02 IBM 3.1.4.53 GO:0004114 ... Q08499 14668322 BindingDB: IC50=31000nM
    6 1zkn:D (2.1) BS02 IBM 3.1.4.53 GO:0004114 ... Q08499 14668322 BindingDB: IC50=31000nM
    7 2hd1:A (2.23) BS02 IBM 3.1.4.35 GO:0004114 ... O76083 15210993 MOAD: ic50~500uM
    PDBbind: -logKd/Ki=3.30, IC50=500uM
    BindingDB: IC50=>200000nM
    8 2hd1:B (2.23) BS02 IBM 3.1.4.35 GO:0004114 ... O76083 15210993 MOAD: ic50~500uM
    BindingDB: IC50=>200000nM
    9 2r8q:A (1.5) BS02 IBM 3.1.4.- GO:0004114 ... Q6S996 17944832 MOAD: ic50=580uM
    PDBbind: -logKd/Ki=3.24, IC50=580uM
    BindingDB: IC50=580000nM
    10 3ecn:A (2.1) BS01 IBM 3.1.4.53 GO:0004114 ... O60658 18983167 MOAD: ic50=698uM
    PDBbind: -logKd/Ki=3.16, IC50=698uM
    BindingDB: IC50=700000nM
    11 3ecn:B (2.1) BS01 IBM 3.1.4.53 GO:0004114 ... O60658 18983167 MOAD: ic50=698uM
    BindingDB: IC50=700000nM
    12 3jwr:A (2.994) BS04 IBM 3.1.4.35 GO:0004114 ... O76074
    P51160    		 19798052 PDBbind: -logKd/Ki=8.07, Ki=8.5nM
    13 3jwr:A (2.994) BS05 IBM 3.1.4.35 GO:0004114 ... O76074
    P51160    		 19798052 PDBbind: -logKd/Ki=8.07, Ki=8.5nM
    14 3jwr:A (2.994) BS06 IBM 3.1.4.35 GO:0004114 ... O76074
    P51160    		 19798052 PDBbind: -logKd/Ki=8.07, Ki=8.5nM
    15 3jwr:B (2.994) BS03 IBM 3.1.4.35 GO:0004114 ... O76074
    P51160    		 19798052
    16 3jwr:B (2.994) BS04 IBM 3.1.4.35 GO:0004114 ... O76074
    P51160    		 19798052
    17 6cpt:A (1.9) BS02 IBM 3.1.4.- GO:0004114 ... Q8NJP9 30231198
    Reference:
    • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
    • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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