BioLiP

Structure of PDB 5vyc Chain k4

Receptor sequence

>5vyck4 (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]

MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPV
KIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKG
AIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKM
SAEDIEKVNKGIGIENIHYLNDGLWHMKTYK

3D structure

PDB

5vyc Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.

Chain

Resolution

6.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	k4	Q16 K18 T19 S20	Q16 K18 T19 S20
BS02	rna	k4	F104 A109 N110	F104 A109 N110

Gene Ontology

	Molecular Function
GO:0000339	RNA cap binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0043024	ribosomal small subunit binding
GO:0045183	translation factor activity, non-nucleic acid binding

	Biological Process
GO:0001731	formation of translation preinitiation complex
GO:0002188	translation reinitiation
GO:0006412	translation
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0006974	DNA damage response
GO:0032790	ribosome disassembly
GO:0075522	IRES-dependent viral translational initiation

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

PDB	RCSB:5vyc, PDBe:5vyc, PDBj:5vyc
PDBsum	5vyc
PubMed	28723557
UniProt	Q9ULC4\|MCTS1_HUMAN Malignant T-cell-amplified sequence 1 (Gene Name=MCTS1)