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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
ssr3_rat D124E ssr5_rat G259F ssr5_rat F265Y
trfr_mouse R283E trfr_mouse R283L trfr_mouse R283S
v1ar_rat D97A v1ar_rat Q104A v1ar_rat Q108A
v1ar_rat Q131A v1ar_rat Q185A v1ar_rat T223A
v1ar_rat Q317A aa2ar_human H278Q aa2ar_human H278F
aa2ar_human H278Y 5ht1d_human T342N 5ht1e_human T330N
5ht1f_human A333N ada2a_pig D79Q ada2a_pig D79E
lshr_human I542L lshr_human D578Y lshr_human C581R
lshr_human A593P lshr_human A572V lshr_human T577I
tshr_human D633E tshr_human D633Y tshr_human F631L
tshr_rat P556L agtr1_human N111A agtr1_human N294A
agtra_rat D74H agtra_rat D74Y agtra_rat F259A
agtra_rat T260A agtra_rat W253A agtra_rat H256I
agtra_rat H256F agtra_rat N295S ednra_human G97A
ednra_human Q165D ednra_human T172V ednra_human S213A
ednra_human F264L ednra_human F260Y ednra_human Y263F
ednra_human R326Q ednra_human H323F ednra_human F315L
ednra_human N361A ednra_human D351N ednra_human D126A
acthr_human S74I ednrb_human D154A ednrb_human D147A
ednrb_human W276C nk1r_rat E78D nk1r_rat E78Q
nk1r_rat E78K v2r_human A61V v2r_human Y128S
v2r_human P286R p2ry2_mouse R265L p2ry2_mouse H262L
drd2_human I109C drd2_human F110C drd2_human V111C
drd2_human T112C drd2_human L113C drd2_human V115C
drd2_human M116C drd2_human T119C drd2_human A120C
drd2_human S121C drd2_human I122C drd2_human L123C
drd2_human N124C drd2_human L125C drd2_human A127C
drd2_human I128C drd2_human S129C drd2_human I130C
agtrb_rat S109T agtrb_rat F110L agtrb_rat A114T
agtrb_rat S115T agtrb_rat L143M agtrb_rat A73S
agtrb_rat S109I agtrb_rat T33I agtrb_rat I37T


Reference:

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