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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
vg74_hhv8 Y144F vg74_hhv8 R208H vg74_hhv8 R278A
vg74_hhv8 R279A vg74_hhv8 C286A glr_human F184A
glr_human K187R glr_human I194K glr_human Y239A
glr_human A348N glr_human V360T glr_human V364I
glr_human T369M glr_human F384T glr_human D385E
glr_rat H178R glr_rat K188R glr_rat I195K
glr_rat I195R glr_rat T352P ghrhr_human H137L
ghrhr_human H137Y ghrhr_human L144H ghrhr_human F242C
ghrhr_human W250X ghrhr_human V254M ghrhr_human G294R
sctr_human R339A sctr_human R339E sctr_human R339I
sctr_human R342A sctr_human R342I sctr_rat I186M
sctr_rat R188 sctr_rat N192 sctr_rat N192I
sctr_rat K195 sctr_rat K195H sctr_rat K195I
sctr_rat D196 sctr_rat D196A sctr_rat D196N
sctr_rat R277D sctr_rat R277Q sctr_rat R299E
sctr_rat R299Q sctr_rat T344P sctr_rat E373A
sctr_rat E373Q sctr_rat E373V vipr1_human D196A
vipr1_human L199A vipr1_mouse V220Q vipr1_pig F12K
bacr_halsa Electron Microscopy 7 TMhelix x-y coordinates 7.99 22.61 14.39 29.79 23.05 28.00 32.36 29.79 36.84 20.29 27.98 11.45 19.89 12.29 bacr_halhp Neutron Diffraction 7 TMhelix x-y coordinates 28.98 33.39 35.37 26.20 44.15 22.50 51.66 26.20 49.85 35.85 42.46 33.67 35.49 38.49 bacr_halhs Neutron Diffraction 7 TMhelix x-y coordinates 36.72 20.29 28.09 27.33 17.66 30.22 9.46 22.75 12.15 11.44 21.24 15.7430.33 12.01
prrg_prb01 Electron Microscopy 7 TMhelix x-y coordinates 6.33 20.28 12.73 23.73 20.24 22.08 27.75 23.60 31.67 16.55 24.17 9.65 18.23 10.63 drd1_human C106A drd1_human S107G
drd1_human S199V drd1_human S202A drd1_human D70V
drd1_human C283V drd1_human F319L drd1_human W321Y
drd2_human M116L drd2_human M117C drd2_human D114G
drd2_human M117L acm2_human D69N hrh2_canfa D186N
hrh2_canfa D98N hrh2_canfa T190C opsd_bovin M86E
opsd_bovin D83E opsd_bovin D83A opsd_bovin T58R
opsd_bovin T58M opsd_bovin T58V opsd_bovin T58A
opsd_bovin T58S opsd_bovin K296R opsd_bovin K296F
opsd_bovin K296A opsd_bovin K296T opsd_bovin K296C
opsd_bovin K296Q opsd_bovin K296V opsd_bovin K296L
opsd_bovin C167S opsd_bovin C222S opsd_bovin C264S


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