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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
gnrr2_claga K124M trfr_mouse N43A trfr_mouse N43D
trfr_mouse D71A trfr_mouse D71N trfr_mouse C98A
trfr_mouse C98S trfr_mouse C100A trfr_mouse Q105A
trfr_mouse Q105V trfr_mouse Y106F trfr_mouse F199A
trfr_mouse Y200A trfr_mouse Y200F trfr_mouse W279A
trfr_mouse Y282A trfr_mouse Y282F trfr_mouse Y282H
trfr_mouse Y282N trfr_mouse Y282S trfr_mouse R283A
trfr_mouse R283H trfr_mouse R283K trfr_mouse R306A
trfr_mouse R306E trfr_mouse R306K trfr_mouse R306L
trfr_mouse N316A trfr_mouse N316D trfr_rat D71A
trfr_rat Y93A trfr_rat F199A ghsr_human D99N
ghsr_human M213K ghsr_human S217A ghsr_human F279L
ghsr_human H280F 5ht1a_human A50V 5ht1a_human A155G
5ht1a_human M172I 5ht1a_human L381F 5ht1d_mouse T354N
5ht2b_human D100N 5ht2b_human D135A 5ht2b_human S139A
5ht2b_human A187S 5ht2b_human S222A 5ht2b_human T228A
5ht2b_human P229A 5ht2b_human A231T 5ht2b_human W337A
5ht2b_human F341A 5ht2b_human N344A 5ht2b_human N376D
5ht2b_mouse A79S 5ht4r_mouse D100A 5ht4r_mouse S197A
5ht4r_mouse W272A 5ht4r_mouse F275A 5ht4r_mouse N308D
5ht6r_rat N288S ssr1_human S305F ssr3_rat D124
ssr5_human L48M ssr5_human A52V ssr5_human I62N
ssr5_human Y304A oxyr_human N57A oxyr_human M78A
oxyr_human D85A oxyr_human D85E oxyr_human D85N
oxyr_human M123A oxyr_human W203L oxyr_human Y209A
oxyr_human Y209F oxyr_human F284A oxyr_human F284Y
oxyr_human F293I oxyr_human M296A oxyr_human M296T
oxyr_human M315A oxyr_human M330A us28_hcmva E124D
us28_hcmva E124Q us28_hcmva E277Q vg74_hhv8 C39A
vg74_hhv8 D83A vg74_hhv8 D83N vg74_hhv8 Y144A
vg74_hhv8 Y144F vg74_hhv8 R208H vg74_hhv8 R278A


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