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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
casr_human Y744-Y779  [Contact Restraint] casr_human Y779-Y825  [Contact Restraint] casr_human Y825-Y858  [Contact Restraint]
casr_human Y858-V728  [Contact Restraint] casr_human V728-V817  [Contact Restraint] casr_human V817-V838  [Contact Restraint]
v2r_human A125-A163  [Contact Restraint] v2r_human A84-N55  [Contact Restraint] v2r_human N55-D85  [Contact Restraint]
v2r_human D85-Q119  [Contact Restraint] v2r_human G56-G79  [Contact Restraint] v2r_human M212-F166  [Contact Restraint]
v2r_human Y124-V160  [Contact Restraint] v2r_human V47-V88  [Contact Restraint] mshr_human F175-F196  [Contact Restraint]
mshr_human F196-Y182  [Contact Restraint] mshr_human Y182-F195  [Contact Restraint] crfr1_mouse C128-C211  [Contact Restraint]
crfr1_mouse C211-C233  [Contact Restraint] ada1b_mesau S207-C129  [Contact Restraint] ada1b_mesau C129-S173  [Contact Restraint]
ada1b_mesau S173-Y213  [Contact Restraint] ada1b_mesau Y213-C306  [Contact Restraint] ada1b_mesau C306-Y338  [Contact Restraint]
acm2_pig D103-D69  [Contact Restraint] nk2r_human M252-T125  [Contact Restraint] ntr1_rat H348-L66  [Contact Restraint]
crfr1_mouse C233-C364  [Contact Restraint] glr_rat T352-H178  [Contact Restraint] glr_rat H178-T352  [Contact Restraint]
5ht2a_rat W200-W336  [Contact Restraint] 5ht2a_rat W336-F365  [Contact Restraint] 5ht6r_rat T196-A154  [Contact Restraint]
ada1b_mesau Y338-S135  [Contact Restraint] casr_human L773-F806  [Contact Restraint] 5ht2a_rat S239-S207  [Contact Restraint]
sctr_human I353-A375  [Contact Restraint] grm4_rat A595-A631  [Contact Restraint] grm4_rat A631-A668  [Contact Restraint]
grm4_rat A668-A701  [Contact Restraint] grm4_rat A701-A771  [Contact Restraint] grm4_rat A771-A800  [Contact Restraint]
grm4_rat A800-A830  [Contact Restraint] grm4_rat A830-C636  [Contact Restraint] grm4_rat C636-C715  [Contact Restraint]
grm4_rat C715-C755  [Contact Restraint] grm4_rat C755-C795  [Contact Restraint] grm4_rat C795-Q710  [Contact Restraint]
grm4_rat Q710-G598  [Contact Restraint] grm4_rat G598-G632  [Contact Restraint] grm4_rat G632-G660  [Contact Restraint]
grm4_rat G660-G713  [Contact Restraint] grm4_rat G713-G758  [Contact Restraint] grm4_rat G758-G788  [Contact Restraint]
grm4_rat G788-G835  [Contact Restraint] grm4_rat G835-I599  [Contact Restraint] grm4_rat I599-I633  [Contact Restraint]
grm4_rat I633-I657  [Contact Restraint] grm4_rat I657-I702  [Contact Restraint] grm4_rat I702-I754  [Contact Restraint]
grm4_rat I754-I787  [Contact Restraint] grm4_rat I787-L590  [Contact Restraint] grm4_rat L590-L625  [Contact Restraint]
grm4_rat L625-L659  [Contact Restraint] grm4_rat L659-L700  [Contact Restraint] grm4_rat L700-L751  [Contact Restraint]
grm4_rat L751-L799  [Contact Restraint] grm4_rat L799-L822  [Contact Restraint] grm4_rat L822-M643  [Contact Restraint]
grm4_rat M643-M663  [Contact Restraint] grm4_rat M663-M761  [Contact Restraint] grm4_rat M761-M791  [Contact Restraint]
grm4_rat M791-M836  [Contact Restraint] grm4_rat M836-F593  [Contact Restraint] grm4_rat F593-F634  [Contact Restraint]
grm4_rat F634-F658  [Contact Restraint] grm4_rat F658-F704  [Contact Restraint] grm4_rat F704-F789  [Contact Restraint]
grm4_rat F789-P591  [Contact Restraint] grm4_rat P591-P786  [Contact Restraint] grm4_rat P786-S626  [Contact Restraint]
grm4_rat S626-S664  [Contact Restraint] grm4_rat S664-S708  [Contact Restraint] grm4_rat S708-S752  [Contact Restraint]
grm4_rat S752-S825  [Contact Restraint] grm4_rat S825-T602  [Contact Restraint] grm4_rat T602-T639  [Contact Restraint]
grm4_rat T639-T703  [Contact Restraint] grm4_rat T703-T766  [Contact Restraint] grm4_rat T766-T790  [Contact Restraint]
grm4_rat T790-T823  [Contact Restraint] grm4_rat T823-W717  [Contact Restraint] grm4_rat W717-W798  [Contact Restraint]


Reference:

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