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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
galr1_human H112Q galr1_human H264A galr1_human H267A
galr1_human H289S adrb2_human L310F adrb2_human L311F
aa2ar_human E13Q drd2_human C118M drd2_human C118A
drd4_human V194G drd2_human F198A drd2_human F389A
drd2_human F411A drd2_human L387A acm2_human D103E
acm2_human D103N acm2_rat D103E acm3_rat A494
acm3_rat A498 acm3_rat A544 acm3_rat N535
acm3_rat N539 acm3_rat C532 acm3_rat C542
acm3_rat C546 acm3_rat G528 acm3_rat I495
acm3_rat I500 acm3_rat I501 acm3_rat I508
acm3_rat I534 acm3_rat L492 acm3_rat L496
acm3_rat L497 acm3_rat L527 acm3_rat L531
acm3_rat L545 acm3_rat M509 acm3_rat F499
acm3_rat P505 acm3_rat P540 acm3_rat S493
acm3_rat S536 acm3_rat T502 acm3_rat T504
acm3_rat T537 acm3_rat W503 acm3_rat W530
acm3_rat Y529 acm3_rat Y543 acm3_rat V510
acm3_rat V538 acm3_rat V541 5ht2c_human A222S
5ht2a_human S159A 5ht2a_human S159C pe2r3_mouse T221A
pe2r3_mouse S268A pe2r3_mouse S272A pe2r3_mouse S268T
pe2r3_mouse T221S pe2r3_mouse S272T grpr_rat Y324A
c5ar_human D82A c5ar_human R206A c5ar_human R206K
c5ar_human R206Q c5ar_human N119A c5ar_human T168A
c5ar_human Q259A ednra_human Y129W ednra_human Y129I
ednra_human Y129T npy1r_human W163A npy1r_human S170A
npy1r_human F173A npy1r_human L174A npy1r_human Q219A
npy1r_human T280A npy1r_human N283A npy1r_human T284A
oprm_rat C235S oprm_rat C292S oprm_rat C321S
oprm_rat A73 oprm_rat N86 oprm_rat C79
oprm_rat G82 oprm_rat G85 oprm_rat I71
oprm_rat I77 oprm_rat L74 oprm_rat L83


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