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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
nk1r_human E78Q nk1r_human N85Q nk1r_human N85S
nk1r_human N85A nk1r_human Y205A nk1r_human Y287Q
nk1r_human Y287F nk1r_human Y287W nk1r_human Y287A
nk1r_human Y287S nk1r_human Y287H nk1r_human H265Y
nk1r_human H265A nk1r_human H265Q nk1r_human H265F
nk1r_human H265S nk2r_human H267Y ednra_human Y129A
ednra_human Y129H ednra_human S167A ednra_human G261A
ednra_human F320A ednra_human Y129F ednra_human Y129K
ednra_human Y129N ednra_human Y129S ednra_human Y129Q
ednrb_human H150A ednrb_human H150Y agtr1_human A283G
agtr1_human N295S agtra_rat D74N agtra_rat D74E
agtra_rat Y292F ssr2_mouse D89N gasr_human V349L
drd2_mouse Y417F mshr_human F179A mshr_human H260A
lshr_human D578G acm1_rat C69S acm1_rat C407S
acm1_rat C417S acm1_rat C421S tshr_human P556L
gnrhr_mouse E90Q gasr_rat V354L tshr_human T632I
tshr_human F631C tshr_human V509A tshr_human C672Y
trfr_mouse T102V trfr_mouse Y103F nk2r_human Q109H
nk2r_human M117L nk2r_human L160F nk2r_human C167G
nk2r_human H198L nk2r_human I202V nk2r_human L292I
nk2r_human L292S nk1r_human M81A nk1r_human N109A
nk1r_human P112A nk1r_human P164A nk1r_human Q165A
nk1r_human Q165S nk1r_human Q165N nk1r_human Y168A
acm1_human S368A adrb2_human C77V adrb2_human C116V
adrb2_human C125V adrb2_human C285V 5ht2a_rat F339A
5ht2a_rat F340A 5ht2a_rat F339Y 5ht2a_rat F340Y
adrb2_human N322A adrb2_human N322D adrb2_human P323A
adrb2_human Y326F agtra_rat N111A agtra_rat S105A
agtra_rat S107A agtra_rat S109A oprm_rat I144L
ssr2_rat D89A ssr2_rat D89E ssr3_rat D124N
ssr3_rat D124E ssr5_rat G259F ssr5_rat F265Y


Reference:

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