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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
opsd_bovin C167S opsd_bovin C222S opsd_bovin C264S
opsd_bovin E122K opsd_bovin F115D opsd_bovin F116D
opsd_bovin T118D opsd_bovin G120D opsd_bovin G121D
opsd_bovin E122I opsd_bovin H211E opsd_bovin F293E
opsd_bovin A299E opsd_bovin V300E opsd_bovin A164S
opsd_bovin F261Y opsd_bovin A269T nk1r_human C152F
nk1r_human I290S nk1r_human S80C nk1r_human V116L
nk1r_human I266V nk1r_human H108Q nk1r_human M291F
nk1r_rat L116V nk1r_rat S290I nk1r_rat V266I
nk1r_rat H265A nk1r_rat G166C nk1r_rat Y167F
nk1r_rat C80S nk1r_rat F152C nmbr_rat L222V
nmbr_rat F221Y nmbr_rat Y220F nmbr_rat I230V
cxcr1_human E118A cxcr1_human D85A gnrhr_mouse N87D
gnrhr_mouse D318N oprm_rat D114A oprm_rat D147A
oprm_rat D114N oprm_rat D114E oprm_rat D147N
oprm_rat D147E oprm_rat H297A drd2_human C56S
drd2_human C126S drd2_human C168S drd2_human C385S
ednra_human I132A nk3r_rat V121M nk3r_rat L81V
nk3r_rat F88L agtrb_rat S252C agtrb_rat V108I
agtrb_rat S107A agtrb_rat V108L agtrb_rat I258V
agtrb_rat L34I agtrb_rat L79I agtrb_rat K146R
agtrb_rat I151G agtrb_rat G157L agtrb_rat L202V
agtrb_rat F206I agtrb_rat I241M agtrb_rat M243V
agtrb_rat F248L c5ar_human D82N par1_human Y371A
nk1r_rat I204V nk1r_rat L207F nk1r_rat F206C
nk1r_rat F264Y nk1r_rat F267Y nk3r_rat C244F
nk3r_rat I237C nk3r_rat I239T nk3r_rat I240V
nk3r_rat F245L nk3r_rat V242I nk3r_rat I307L
nk3r_rat Y302F nk3r_rat Y305F aa1r_canfa M270I
aa1r_canfa T277S aa1r_bovin S277T opsg_human A180S
opsg_human A285T opsg_human F277Y opsg_human F309Y


Reference:

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