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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
opsd_bovin A117M opsd_bovin A117V opsd_bovin A117W
opsd_bovin G121A opsd_bovin G121I opsd_bovin G121L
opsd_bovin G121S opsd_bovin G121T opsd_bovin G121V
opsd_bovin G121W opsd_bovin E122 opsd_bovin E122A
opsd_bovin E122D opsd_bovin E122H opsd_bovin E122L
opsd_bovin E122Q opsd_bovin E122R opsd_bovin I123R
opsd_bovin A124R opsd_bovin L125A opsd_bovin L125F
opsd_bovin L125R opsd_bovin W126A opsd_bovin W126L
opsd_bovin S127R opsd_bovin L131P opsd_bovin A164V
opsd_bovin C167 opsd_bovin L172A opsd_bovin W175A
opsd_bovin W175C opsd_bovin W175H opsd_bovin V204C
opsd_bovin H211 opsd_bovin H211F opsd_bovin H211N
opsd_bovin H211S opsd_bovin P215L opsd_bovin P215Y
opsd_bovin I219A opsd_bovin C222 opsd_bovin M257A
opsd_bovin V258A opsd_bovin F261A opsd_bovin F261T
opsd_bovin F261V opsd_bovin F261W opsd_bovin C264
opsd_bovin W265A opsd_bovin W265F opsd_bovin W265Y
opsd_bovin P267A opsd_bovin Y268F opsd_bovin F276C
opsd_bovin T289P opsd_bovin A292 opsd_bovin A292D
opsd_bovin A292E opsd_bovin K296E opsd_bovin K296G
opsd_bovin K296H opsd_bovin K296M opsd_bovin N302A
opsd_bovin P303A opsd_bovin Y306A opsd_bovin Y306C
opsd_mouse V87D opsd_mouse G89D opsd_mouse G90D
opsd_mouse T94D opsd_mouse T94I opsd_mouse T94K
opsd_mouse T94S opsd_mouse E113Q opsd_mouse M257A
opsd_mouse A269G opsd_mouse I286A opsd_mouse A292E
opsd_ranpi Electron Microscopy 7 TMhelix x-y coordinates 6.99 14.20 12.73 24.69 20.70 22.08 28.55 23.88 28.98 13.10 21.47 7.47 14.62 12.96 opsd_todpa Electron Microscopy 7 TMhelix x-y coordinates 11.70 11.87 9.23 23.60 16.20 29.93 24.28 25.92 32.14 22.36 25.86 16.13 18.89 16.97 opsx_human I49A
opsx_human S82A opsx_human G109A opsx_human L116T
pe2r2_human Y111A pe2r2_human S120G pe2r2_human R302E
pe2r2_human R302Q pe2r2_human L304Y pe2r2_human S305A
pe2r2_human F315Y ta2r_human C35S ta2r_human V36A


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