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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
aa1r_mouse I274A aa1r_mouse T277A aa1r_mouse T277S
aa1r_mouse H278A aa1r_mouse H278L aa1r_mouse H278Y
aa1r_mouse S281A aa1r_mouse S281N aa1r_mouse S281T
aa1r_rat L65T aa3r_human E19X aa3r_human N30A
aa3r_human C88F aa3r_human H95 aa3r_human H95A
aa3r_human W243 aa3r_human W243A aa3r_human W243F
aa3r_human L244A aa3r_human S247A aa3r_human S247H
aa3r_human N250A aa3r_human H272E aa3r_human Y282F
p2ry1_human F131A p2ry1_human H132A p2ry1_human Y136A
p2ry1_human T222A p2ry1_human F226A p2ry1_human H277A
p2ry1_chick Disulfied Bridge Cys124-Cys202 and Cys42-Cys296 p2ry4_human S177N p2ry4_human N178A
p2ry4_human K179N ada1b_human D125A ada1b_human D125K
ada1b_mesau N63A ada1b_mesau D125 ada1b_mesau D125A
ada1b_mesau D125K ada1b_mesau C128F ada1b_mesau C128S
ada1b_mesau C129S ada1b_mesau C137S ada1b_mesau A204V
ada1b_mesau S207 ada1b_mesau F303A ada1b_mesau F303G
ada1b_mesau F303L ada1b_mesau F303N ada1b_mesau F310A
ada1b_mesau F310C ada1b_mesau F310L ada1b_mesau F310W
ada1b_mesau F311A ada1b_mesau F311C ada1b_mesau F311L
ada1b_mesau Y348A ada1b_mesau Y348L ada2a_mouse D79N
ada2a_rat S165A ada2b_human T370K ada2c_human S189C
ada2c_human S189L ada2c_human S189M ada2c_human T381K
adrb2_bovin D130N adrb2_bovin C285S adrb2_mesau D113
agtr2_human I53F agtr2_human I217V agtr2_human D297K
agtr2_rat N127G agtr2_rat H273E agtr2_rat H273R
nmbr_rat I216S grpr_mouse I117L grpr_mouse Q121R
grpr_mouse L172F grpr_mouse S180A grpr_mouse S212A
grpr_mouse S215A grpr_mouse F216A grpr_mouse F270A
grpr_mouse W278A grpr_mouse N281A grpr_mouse Y285A
grpr_mouse S305T grpr_mouse A308S grpr_mouse R309A
grpr_mouse R309D grpr_mouse F313A brs3_human R127Q


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