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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
cxcr4_human F87-S46  [Contact Restraint] cxcr4_human S46-S81  [Contact Restraint] cxcr4_human S81-T51  [Contact Restraint]
cxcr4_human T51-T90  [Contact Restraint] cxcr4_human T90-Y45  [Contact Restraint] cxcr4_human Y45-V112  [Contact Restraint]
cxcr4_human V112-V54  [Contact Restraint] cxcr4_human V54-V82  [Contact Restraint] nk1r_human I204-A115  [Contact Restraint]
5ht4r_human S197-F275  [Contact Restraint] 5ht6r_rat A287-W102  [Contact Restraint] gnrhr_mouse D318-N53  [Contact Restraint]
cnr1_rat N394-D164  [Contact Restraint] 5ht4r_human Y302-D66  [Contact Restraint] 5ht4r_human D66-D100  [Contact Restraint]
gasr_human G135-M186  [Contact Restraint] gasr_human W346-S379  [Contact Restraint] lshr_rat L612-N539  [Contact Restraint]
lshr_rat N619-E455  [Contact Restraint] lshr_human D578-I625  [Contact Restraint] lshr_human I625-D405  [Contact Restraint]
lshr_human D405-Y546  [Contact Restraint] opsd_human E134  [FTIR] opsd_human E181  [FTIR]
opsd_human K296  [FTIR] opsd_human V250  [FTIR] opsd_human V227  [FTIR]
opsd_human Y29  [FTIR] opsd_human Y102  [FTIR] opsd_human Y274  [FTIR]
acm1_human D71N acm1_human Y82F acm1_human T192A
acm1_human W209A acm1_human N382A acm1_human S388Y
acm1_human T389P acm1_human T389Y acm1_human M416A
acm1_human C417R acm1_human C417S acm1_rat D71N
acm1_rat D99N acm1_rat W101A acm1_rat L102A
acm1_rat D105A acm1_rat D105E acm1_rat D105N
acm1_rat Y106A acm1_rat Y106N acm1_rat S109A
acm1_rat N110A acm1_rat S112A acm1_rat V113A
acm1_rat N115A acm1_rat L116A acm1_rat I119A
acm1_rat S120A acm1_rat M145A acm1_rat L148A
acm1_rat W150A acm1_rat L151A acm1_rat S153A
acm1_rat W157A acm1_rat P159A acm1_rat A160G
acm1_rat I161A acm1_rat F163A acm1_rat F190C
acm1_rat T192C acm1_rat A193C acm1_rat A193G
acm1_rat W378A acm1_rat Y381A acm1_rat Y381F
acm1_rat Y381N acm1_rat N382A acm1_rat L386A
acm1_rat V387A acm1_rat L402A acm1_rat Y404A
acm1_rat Y404F acm1_rat W405A acm1_rat C407A
acm1_rat Y408A acm1_rat Y408F acm1_rat N410A
acm1_rat S411A acm1_rat T412A acm1_rat V413A
acm1_rat N414A acm1_rat P415A acm1_rat M416A


Reference:

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