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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
oprd_mouse I304-L219  [Contact Restraint] oprd_mouse L219-L300  [Contact Restraint] oprd_mouse L300-F218  [Contact Restraint]
oprd_mouse F218-F270  [Contact Restraint] oprd_mouse F270-P225  [Contact Restraint] oprd_mouse P225-P276  [Contact Restraint]
oprd_mouse P276-T230  [Contact Restraint] oprd_mouse T230-W274  [Contact Restraint] oprd_mouse W274-Y233  [Contact Restraint]
oprd_mouse Y233-Y308  [Contact Restraint] oprd_mouse Y308-V217  [Contact Restraint] oprd_mouse V217-V265  [Contact Restraint]
ada2a_pig A377-N418  [Contact Restraint] ada2a_pig N418-C386  [Contact Restraint] ada2a_pig C386-C417  [Contact Restraint]
ada2a_pig C417-G381  [Contact Restraint] ada2a_pig G381-G415  [Contact Restraint] ada2a_pig G415-I380  [Contact Restraint]
ada2a_pig I380-I425  [Contact Restraint] ada2a_pig I425-L376  [Contact Restraint] ada2a_pig L376-L421  [Contact Restraint]
ada2a_pig L421-F383  [Contact Restraint] ada2a_pig F383-F410  [Contact Restraint] ada2a_pig F410-P389  [Contact Restraint]
ada2a_pig P389-P423  [Contact Restraint] ada2a_pig P423-T393  [Contact Restraint] ada2a_pig T393-T427  [Contact Restraint]
ada2a_pig T427-W387  [Contact Restraint] ada2a_pig W387-W413  [Contact Restraint] ada2a_pig W413-Y394  [Contact Restraint]
ada2a_pig Y394-Y416  [Contact Restraint] ada2a_pig Y416-V375  [Contact Restraint] ada2a_pig V375-V424  [Contact Restraint]
ada2a_pig V424-D113  [Contact Restraint] adrb1_rat S232-F350  [Contact Restraint] v1ar_rat C237-C349  [Contact Restraint]
gasr_rat V187-A147  [Contact Restraint] gasr_rat A147-L180  [Contact Restraint] lshr_rat A377-A408  [Contact Restraint]
lshr_rat A408-A445  [Contact Restraint] lshr_rat A445-A487  [Contact Restraint] lshr_rat A487-A542  [Contact Restraint]
lshr_rat A542-A587  [Contact Restraint] lshr_rat A587-A622  [Contact Restraint] lshr_rat A622-N374  [Contact Restraint]
lshr_rat N374-N404  [Contact Restraint] lshr_rat N404-N539  [Contact Restraint] lshr_rat N539-N619  [Contact Restraint]
lshr_rat N619-D582  [Contact Restraint] lshr_rat D582-C403  [Contact Restraint] lshr_rat C403-C547  [Contact Restraint]
lshr_rat C547-C585  [Contact Restraint] lshr_rat C585-C621  [Contact Restraint] lshr_rat C621-E455  [Contact Restraint]
lshr_rat E455-G380  [Contact Restraint] lshr_rat G380-G413  [Contact Restraint] lshr_rat G413-G444  [Contact Restraint]
lshr_rat G444-G493  [Contact Restraint] lshr_rat G493-I370  [Contact Restraint] lshr_rat I370-I464  [Contact Restraint]
lshr_rat I464-I488  [Contact Restraint] lshr_rat I488-I532  [Contact Restraint] lshr_rat I532-I589  [Contact Restraint]
lshr_rat I589-I610  [Contact Restraint] lshr_rat I610-L372  [Contact Restraint] lshr_rat L372-L401  [Contact Restraint]
lshr_rat L401-L456  [Contact Restraint] lshr_rat L456-L492  [Contact Restraint] lshr_rat L492-L533  [Contact Restraint]
lshr_rat L533-L611  [Contact Restraint] lshr_rat L611-M402  [Contact Restraint] lshr_rat M402-M491  [Contact Restraint]
lshr_rat M491-M586  [Contact Restraint] lshr_rat M586-F379  [Contact Restraint] lshr_rat F379-F400  [Contact Restraint]
lshr_rat F400-F448  [Contact Restraint] lshr_rat F448-F497  [Contact Restraint] lshr_rat F497-F543  [Contact Restraint]
lshr_rat F543-F583  [Contact Restraint] lshr_rat F583-F615  [Contact Restraint] lshr_rat F615-P489  [Contact Restraint]
lshr_rat P617-S406  [Contact Restraint] lshr_rat S406-S454  [Contact Restraint] lshr_rat S454-S498  [Contact Restraint]
lshr_rat S498-S534  [Contact Restraint] lshr_rat S534-S590  [Contact Restraint] lshr_rat S590-S620  [Contact Restraint]
lshr_rat S620-T383  [Contact Restraint] lshr_rat T383-T450  [Contact Restraint] lshr_rat T450-T499  [Contact Restraint]
lshr_rat T499-T584  [Contact Restraint] lshr_rat T584-W371  [Contact Restraint] lshr_rat W371-W495  [Contact Restraint]


Reference:

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