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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
nk1r_rat I303-L262  [Contact Restraint] nk1r_rat L262-L288  [Contact Restraint] nk1r_rat L288-M249  [Contact Restraint]
nk1r_rat M249-M291  [Contact Restraint] nk1r_rat M291-F257  [Contact Restraint] nk1r_rat F257-P302  [Contact Restraint]
nk1r_rat P302-T256  [Contact Restraint] nk1r_rat T256-T298  [Contact Restraint] nk1r_rat T298-W261  [Contact Restraint]
nk1r_rat W261-W292  [Contact Restraint] nk1r_rat W292-V252  [Contact Restraint] nk1r_rat V252-V286  [Contact Restraint]
nk1r_rat V286-A114  [Contact Restraint] nk1r_rat A114-A158  [Contact Restraint] nk1r_rat A158-A215  [Contact Restraint]
nk1r_rat A215-A75  [Contact Restraint] nk1r_rat A75-N109  [Contact Restraint] nk1r_rat N109-N73  [Contact Restraint]
nk1r_rat N73-Q165  [Contact Restraint] nk1r_rat Q165-E78  [Contact Restraint] nk1r_rat E78-G166  [Contact Restraint]
nk1r_rat G166-G213  [Contact Restraint] nk1r_rat G213-H108  [Contact Restraint] nk1r_rat H108-I151  [Contact Restraint]
nk1r_rat I151-I204  [Contact Restraint] nk1r_rat I204-L116  [Contact Restraint] nk1r_rat L116-L157  [Contact Restraint]
nk1r_rat L157-L203  [Contact Restraint] nk1r_rat L203-L71  [Contact Restraint] nk1r_rat L71-M123  [Contact Restraint]
nk1r_rat M123-M81  [Contact Restraint] nk1r_rat M81-F107  [Contact Restraint] nk1r_rat F107-F152  [Contact Restraint]
nk1r_rat F152-F206  [Contact Restraint] nk1r_rat F206-F70  [Contact Restraint] nk1r_rat F70-P112  [Contact Restraint]
nk1r_rat P112-P164  [Contact Restraint] nk1r_rat P164-P208  [Contact Restraint] nk1r_rat P208-S119  [Contact Restraint]
nk1r_rat S119-T217  [Contact Restraint] nk1r_rat T217-T86  [Contact Restraint] nk1r_rat T86-W155  [Contact Restraint]
nk1r_rat W155-Y121  [Contact Restraint] nk1r_rat Y121-Y167  [Contact Restraint] nk1r_rat Y167-Y205  [Contact Restraint]
nk1r_rat Y205-V126  [Contact Restraint] nk1r_rat V126-V149  [Contact Restraint] nk1r_rat V149-V211  [Contact Restraint]
nk1r_rat V211-V72  [Contact Restraint] nk1r_rat V72-A36  [Contact Restraint] oprk_mouse A234-A281  [Contact Restraint]
oprk_mouse A281-A317  [Contact Restraint] oprk_mouse A317-C245  [Contact Restraint] oprk_mouse C245-C286  [Contact Restraint]
oprk_mouse C286-C315  [Contact Restraint] oprk_mouse C315-H291  [Contact Restraint] oprk_mouse H291-I237  [Contact Restraint]
oprk_mouse I237-I284  [Contact Restraint] oprk_mouse I284-I316  [Contact Restraint] oprk_mouse I316-L240  [Contact Restraint]
oprk_mouse L240-L277  [Contact Restraint] oprk_mouse L277-L318  [Contact Restraint] oprk_mouse L318-F231  [Contact Restraint]
oprk_mouse F231-F283  [Contact Restraint] oprk_mouse F283-F314  [Contact Restraint] oprk_mouse F314-P238  [Contact Restraint]
oprk_mouse P238-P289  [Contact Restraint] oprk_mouse P289-P327  [Contact Restraint] oprk_mouse P327-T247  [Contact Restraint]
oprk_mouse T247-T288  [Contact Restraint] oprk_mouse T288-T321  [Contact Restraint] oprk_mouse T321-W287  [Contact Restraint]
oprk_mouse W287-Y246  [Contact Restraint] oprk_mouse Y246-Y312  [Contact Restraint] oprk_mouse Y312-V232  [Contact Restraint]
oprk_mouse V232-V276  [Contact Restraint] oprk_mouse V276-V328  [Contact Restraint] oprd_mouse A221-A269  [Contact Restraint]
oprd_mouse A269-A299  [Contact Restraint] oprd_mouse A299-C216  [Contact Restraint] oprd_mouse C216-C273  [Contact Restraint]
oprd_mouse C273-C303  [Contact Restraint] oprd_mouse C303-G234  [Contact Restraint] oprd_mouse G234-G268  [Contact Restraint]
oprd_mouse G268-G307  [Contact Restraint] oprd_mouse G307-H278  [Contact Restraint] oprd_mouse H278-H301  [Contact Restraint]
oprd_mouse H301-I226  [Contact Restraint] oprd_mouse I226-I277  [Contact Restraint] oprd_mouse I277-I304  [Contact Restraint]
oprd_mouse I304-L219  [Contact Restraint] oprd_mouse L219-L300  [Contact Restraint] oprd_mouse L300-F218  [Contact Restraint]


Reference:

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