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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
acm3_rat S493-S536  [Contact Restraint] acm3_rat S536-T502  [Contact Restraint] acm3_rat T502-T537  [Contact Restraint]
acm3_rat T537-W503  [Contact Restraint] acm3_rat W530-V510  [Contact Restraint] acm3_rat V510-V538  [Contact Restraint]
pe2r3_mouse T221-S268  [Contact Restraint] pe2r3_mouse S268-T221  [Contact Restraint] pe2r3_mouse T221-S272  [Contact Restraint]
oprm_rat C235-C292  [Contact Restraint] oprm_rat C292-C321  [Contact Restraint] oprm_rat C321-A73  [Contact Restraint]
v2r_human Y280-A314  [Contact Restraint] v2r_human A314-C283  [Contact Restraint] v2r_human L309-F287  [Contact Restraint]
opsd_human F45-V87  [Contact Restraint] tshr_human S505-N670  [Contact Restraint] tshr_rat C636-C454  [Contact Restraint]
tshr_rat C454-C549  [Contact Restraint] tshr_rat C549-C598  [Contact Restraint] tshr_rat C598-C636  [Contact Restraint]
tshr_rat C636-C672  [Contact Restraint] lshr_human S616-A572  [Contact Restraint] lshr_human A572-A618  [Contact Restraint]
lshr_human A618-D578  [Contact Restraint] lshr_human D578-C617  [Contact Restraint] lshr_human C617-I573  [Contact Restraint]
lshr_human I573-I614  [Contact Restraint] lshr_human I614-L574  [Contact Restraint] lshr_human L574-L610  [Contact Restraint]
lshr_human L610-M582  [Contact Restraint] lshr_human M582-F611  [Contact Restraint] lshr_human F611-P584  [Contact Restraint]
lshr_human P584-P613  [Contact Restraint] lshr_human P613-S586  [Contact Restraint] lshr_human S586-S616  [Contact Restraint]
lshr_human S616-T577  [Contact Restraint] lshr_human T577-Y612  [Contact Restraint] aa2ar_human T88-S277  [Contact Restraint]
adrb2_mesau A320-N293  [Contact Restraint] adrb2_mesau N293-N312  [Contact Restraint] adrb2_mesau N312-C285  [Contact Restraint]
adrb2_mesau C285-G315  [Contact Restraint] adrb2_mesau G315-H296  [Contact Restraint] adrb2_mesau H296-I309  [Contact Restraint]
adrb2_mesau I309-L275  [Contact Restraint] adrb2_mesau L275-L310  [Contact Restraint] adrb2_mesau L310-M279  [Contact Restraint]
adrb2_mesau M279-F321  [Contact Restraint] adrb2_mesau F321-P288  [Contact Restraint] adrb2_mesau P288-P323  [Contact Restraint]
adrb2_mesau P323-T281  [Contact Restraint] adrb2_mesau T281-W313  [Contact Restraint] adrb2_mesau W313-V292  [Contact Restraint]
adrb2_mesau V292-V307  [Contact Restraint] acm2_human N432-I392  [Contact Restraint] acm2_human Y403-Y426  [Contact Restraint]
ednrb_rat A141-R124  [Contact Restraint] ednrb_rat R124-N158  [Contact Restraint] ednrb_rat N158-C109  [Contact Restraint]
ednrb_rat C109-G146  [Contact Restraint] ednrb_rat G146-I103  [Contact Restraint] ednrb_rat I103-I138  [Contact Restraint]
ednrb_rat I138-L110  [Contact Restraint] ednrb_rat L110-L139  [Contact Restraint] ednrb_rat L139-F112  [Contact Restraint]
ednrb_rat F112-P156  [Contact Restraint] ednrb_rat P156-S108  [Contact Restraint] ednrb_rat S108-S142  [Contact Restraint]
ednrb_rat S142-T105  [Contact Restraint] ednrb_rat T105-Y160  [Contact Restraint] ednrb_rat Y160-V107  [Contact Restraint]
fpr1_human A68-N44  [Contact Restraint] fpr1_human N44-N66  [Contact Restraint] lshr_rat P489-P588  [Contact Restraint]
lshr_rat P588-P617  [Contact Restraint] cnr1_human F155-A233  [Contact Restraint] aa3r_rat C267-I129  [Contact Restraint]
aa3r_rat I129-L234  [Contact Restraint] ada1b_mesau A204-L314  [Contact Restraint] ada1a_rat V185-M292  [Contact Restraint]
acm5_human I78-A163  [Contact Restraint] acm5_human A163-A446  [Contact Restraint] acm5_human A446-C498  [Contact Restraint]
acm1_pig L367-T202  [Contact Restraint] acm2_pig I201-I389  [Contact Restraint] glr_rat A183-A238  [Contact Restraint]
glr_rat A238-A315  [Contact Restraint] glr_rat A315-A367  [Contact Restraint] glr_rat A367-A398  [Contact Restraint]
glr_rat A398-R309  [Contact Restraint] glr_rat R309-N180  [Contact Restraint] glr_rat N180-N239  [Contact Restraint]


Reference:

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