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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
drd2_human F164C drd2_human T165C drd2_human I166C
drd2_human S167C drd2_human P169C drd2_human L170C
drd2_human L171C drd2_human G173C drd2_human L174C
adrb2_human S203A adrb2_human S203T adrb2_human S203V
gnrhr_mouse N87Q gnrhr_mouse N87A gnrhr_mouse D318E
gnrhr_mouse D318A gnrhr_mouse D318L gnrhr_mouse N53D
pe2r2_human L84F pe2r2_human L90F pe2r2_human L301F
cnr1_rat N394D cnr1_rat D164N tshr_human L426
tshr_human F423 tshr_human S425 tshr_human W422
tshr_human V420 tshr_human V421 tshr_human V424
tshr_human I419R lshr_human D578C agtr2_mouse D297A
nk1r_human A162L acm1_rat I188C acm1_rat I188A
acm1_rat T189C acm1_rat T189S acm1_rat F190A
acm1_rat G191C acm1_rat G191A acm1_rat T192A
acm1_rat M194C acm1_rat A195C acm1_rat A195G
acm1_rat A196C acm1_rat A196G 5ht4r_human D66N
5ht4r_human D100N 5ht4r_human T150V 5ht4r_human S153A
5ht4r_human C196A ccr5_human I42F ccr5_human L55Q
ccr5_human A73V acm1_rat I383A acm1_rat M384A
acm1_rat V385A 5ht6r_rat D106N gasr_human Y61A
gasr_human G135A gasr_human M186A gasr_human L226A
gasr_human F227A gasr_human W346A gasr_human V349A
gasr_human Y350A gasr_human S379A drd3_human S192A
drd3_human S193A drd3_human S196A acm2_human A401T
adrb2_human S203C nk2r_human Q166A nk2r_human Y206F
nk2r_human Y266T nk2r_human H267A gnrhr_mouse N53A
gnrhr_mouse N53L tshr_human L677V ta2r_human S255A
cnr1_human K192R cnr1_human K192Q cnr1_human K192E
cnr1_human G195S cnr1_human A198M cnr2_human W172A
cnr2_human W172F cnr1_human V282F cnr2_human F197V
fshr_human L460R fshr_human L460K fshr_human L460A


Reference:

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