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I-TASSER I-TASSER-MTD C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign CR-I-TASSER GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
adrb2_human N312C adrb2_human H296A adrb2_human D113A
adrb2_human D113C adrb2_human D113H adrb2_human N312H
ada1a_rat F163Q ada1a_rat F187A adrb2_mesau A202F
adrb2_mesau Q170F drd2_human F164A drd2_human L170V
drd2_human T392V drd2_human F411V drd4_rat M109L
drd4_rat L87W drd2_mouse I109T drd2_mouse L113M
drd2_mouse F110L drd2_mouse T112A drd2_mouse V111M
ada2a_human V197S ada2a_human S200S cnr1_human D163E
cnr1_human D163N 5ht1b_human C326A 5ht1b_human D352A
5ht1b_human W327A 5ht2a_rat D155A 5ht2a_rat D155Q
5ht2a_rat D155E 5ht2a_rat N363A hrh1_cavpo F436M
adrb2_human E122A drd4_human C119S 5ht2a_rat F240A
5ht2a_rat F243A 5ht2a_rat F244A agtra_rat L112
agtra_rat S105 agtra_rat V108 agtra_rat V116
agtra_rat A104F agtra_rat S107F agtra_rat Y292G
agtra_rat Y292A agtra_rat Y292Q agtra_rat N295G
agtra_rat N295C agtra_rat N295I agtra_rat N295F
agtra_rat N111C agtra_rat I150 agtra_rat C149
acm5_human V464I ccr2_human A99 ccr1_human I108
cnr1_human V364 cnr1_human A118 drd1_macmu N97
gnrr2_claga D321N gabr1_rat A633 gabr1_rat A639
gabr1_rat A641 gabr1_rat A642 gabr1_rat A711
gabr1_rat A725 gabr1_rat A818 gabr1_rat A838
gabr1_rat A843 gabr1_rat A850 gabr1_rat N841
gabr1_rat D720 gabr1_rat C636 gabr1_rat C846
gabr1_rat Q728 gabr1_rat G635 gabr1_rat G670
gabr1_rat G672 gabr1_rat G676 gabr1_rat G678
gabr1_rat G714 gabr1_rat G718 gabr1_rat G805
gabr1_rat G808 gabr1_rat G814 gabr1_rat G836
gabr1_rat I684 gabr1_rat I726 gabr1_rat I729
gabr1_rat I815 gabr1_rat I839 gabr1_rat I848


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