This page contains 3D structural models (Version 3, built on Aug 2014) of 1,026 putative G protein-coupled receptors (GPCRs) in the human genome generated by the GPCR-I-TASSER pipeline. The most recent (Version 4, built on June 2018) is now available as part of the GPCR-EXP database. In GPCR-I-TASSER, the GPCR sequences are first threaded through the GPCR template library to identify muliple structure templates by the LOMETS programs. When close homolgous templates are identified, full-length models will be constructed by the I-TASSER based fragment assembly simulations, assisted by a GPCR and membrane specific force field and spatial restraints collected from mutagenesis experiments in GPCR-RD. In case that homologous templates are not available, an ab initio folding procedure is used to assemble the 7-TM-helix bundle from scratch, followed by the GPCR-I-TASSER fragment reassembly simulations. For multiple domain GPCRs, structural models are built by GPCR-I-TASSER for each domain separately which are then reassembly by the I-TASSER approach. All the models are finally subjected to FG-MD for fragment-guided molecular dynamic simulation refinements. Note:
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Other GPCR-related resources
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HG ID | UniProt ID | Length | C-score | Estimated TM-score |
Estimated RMSD |
Top 5 models |
HG0550 | Q8NGS6 | 347 | -1.18 | 0.57 ± 0.15 | 9.2 ± 4.6 | |
HG0551 | Q6UR98 | 317 | -0.09 | 0.7 ± 0.12 | 6.5 ± 3.9 | |
HG0552 | P51686 | 369 | -0.25 | 0.68 ± 0.12 | 7.2 ± 4.2 | |
HG0553 | P43088 | 359 | 0.44 | 0.77 ± 0.1 | 5.6 ± 3.6 | |
HG0554 | Q96RD2 | 323 | -0.41 | 0.66 ± 0.13 | 7.2 ± 4.2 | |
HG0555 | Q7Z5H4 | 357 | -2.06 | 0.47 ± 0.15 | 9.99 ± 4.5 | |
HG0556 | Q9UKP6 | 389 | -1.04 | 0.58 ± 0.14 | 9.1 ± 4.6 | |
HG0557 | Q9H255 | 320 | -0.2 | 0.69 ± 0.12 | 6.8 ± 4 | |
HG0558 | Q9Y2T6 | 319 | 0.08 | 0.72 ± 0.11 | 6.2 ± 3.8 | |
HG0559 | Q4VBL9 | 464 | -2.5 | 0.42 ± 0.14 | 9.99 ± 4.1 | |
HG0560 | Q8NFJ5 | 357 | -2.16 | 0.46 ± 0.15 | 9.99 ± 4.5 |
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