This page contains 3D structural models (Version 3, built on Aug 2014) of 1,026 putative G protein-coupled receptors (GPCRs) in the human genome generated by the GPCR-I-TASSER pipeline. The most recent (Version 4, built on June 2018) is now available as part of the GPCR-EXP database. In GPCR-I-TASSER, the GPCR sequences are first threaded through the GPCR template library to identify muliple structure templates by the LOMETS programs. When close homolgous templates are identified, full-length models will be constructed by the I-TASSER based fragment assembly simulations, assisted by a GPCR and membrane specific force field and spatial restraints collected from mutagenesis experiments in GPCR-RD. In case that homologous templates are not available, an ab initio folding procedure is used to assemble the 7-TM-helix bundle from scratch, followed by the GPCR-I-TASSER fragment reassembly simulations. For multiple domain GPCRs, structural models are built by GPCR-I-TASSER for each domain separately which are then reassembly by the I-TASSER approach. All the models are finally subjected to FG-MD for fragment-guided molecular dynamic simulation refinements. Note:
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Other GPCR-related resources
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HG ID | UniProt ID | Length | C-score | Estimated TM-score |
Estimated RMSD |
Top 5 models |
HG0490 | P47883 | 348 | -0.64 | 0.63 ± 0.13 | 7.9 ± 4.4 | |
HG0491 | P30954 | 320 | -0.49 | 0.65 ± 0.13 | 7.4 ± 4.2 | |
HG0492 | Q5ZGX3 | 422 | -0.56 | 0.64 ± 0.13 | 8.2 ± 4.5 | |
HG0493 | Q8NH41 | 348 | -1.43 | 0.54 ± 0.15 | 9.8 ± 4.6 | |
HG0494 | Q6NWR9 | 419 | -0.7 | 0.62 ± 0.14 | 8.5 ± 4.5 | |
HG0495 | P08588 | 477 | -2.32 | 0.44 ± 0.14 | 9.99 ± 4.2 | |
HG0496 | Q8NH04 | 317 | -0.26 | 0.68 ± 0.12 | 6.9 ± 4.1 | |
HG0497 | Q6NWR0 | 337 | -0.26 | 0.68 ± 0.12 | 7 ± 4.1 | |
HG0498 | Q9BYT4 | 265 | 1.11 | 0.87 ± 0.07 | 3.7 ± 2.5 | |
HG0499 | Q9H228 | 398 | -0.77 | 0.62 ± 0.14 | 8.5 ± 4.5 | |
HG0500 | Q8NGN6 | 311 | -0.03 | 0.71 ± 0.12 | 6.3 ± 3.9 |
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