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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL19376
Molecular formula	C19H28N6O3
IUPAC name	(2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-N-tert-butylpiperazine-2-carboxamide
Molecular weight	388.472
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	1.3
Synonyms	(S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazine-2-carboxylic acid tert-butylamide BDBM50063908 (2S)-N-tert-Butyl-4-(4-amino-6,7-dimethoxyquinazoline-2-yl)piperazine-2alpha-carboxamide FACJCZHMOYUSSW-ZDUSSCGKSA-N 4-Amino-6,7-dimethoxy-2-[(3S)-3-(t-butylcarbamoyl)-1-piperazinyl]quinazoline (S)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-3-(1,1-dimethylethylamino)carbonyl piperazine SCHEMBL6442462 [ Show all ]
Inchi Key	FACJCZHMOYUSSW-ZDUSSCGKSA-N
Inchi ID	InChI=1S/C19H28N6O3/c1-19(2,3)24-17(26)13-10-25(7-6-21-13)18-22-12-9-15(28-5)14(27-4)8-11(12)16(20)23-18/h8-9,13,21H,6-7,10H2,1-5H3,(H,24,26)(H2,20,22,23)/t13-/m0/s1
PubChem CID	10739024
ChEMBL	CHEMBL19376
IUPHAR	N/A
BindingDB	50063908
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
73277	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
73282	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
73278	Alpha-1B adrenergic receptor	P15823	Adra1b	Rattus norvegicus (Rat)	515
73280	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
73279	Alpha-1D adrenergic receptor	P23944	Adra1d	Rattus norvegicus (Rat)	561
73281	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572

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