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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	1-Cyclohexyl-1H-benzotriazole-5-carboxylic acid
Molecular formula	C13H15N3O2
IUPAC name	1-cyclohexylbenzotriazole-5-carboxylic acid
Molecular weight	245.282
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.6
Synonyms	BBL026354 KM5711 ST086611 691363-11-8 CHEMBL383099 MolPort-002-004-624 V7316 1-cyclohexyl-1,2,3-benzotriazole-5-carboxylic acid ALBB-025400 HMS1696A18 SEL10044802 1-cyclohexylbenzotriazole-5-carboxylic acid BRD-K07688356-001-09-1 MCULE-2584296256 STL371320 AC1LCP8Y CTK7I8543 SBB011869 ZINC2487601 1-Cyclohexyl-1H-1,2,3-benzotriazole-5-carboxylic acid BAS 06332195 HMS2315I23 SMR000013711 1H-1,2,3-benzotriazole-5-carboxylic acid, 1-cyclohexyl- MLS000068125 TR-043898 AKOS000210384 EU-0017027 SCHEMBL6044076 ZX-AN023914 [ Show all ]
Inchi Key	GLIAIPXYMCWRTG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H15N3O2/c17-13(18)9-6-7-12-11(8-9)14-15-16(12)10-4-2-1-3-5-10/h6-8,10H,1-5H2,(H,17,18)
PubChem CID	653819
ChEMBL	CHEMBL383099
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5888.44 nM	PMID16480258	ChEMBL

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