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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Homo sapiens (Human)
Gene	CHRM5
Synonym	M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5
Disease	Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis Neurological disease Schizophrenia Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Allergic rhinitis Central and peripheral nervous diseases Brain diseases Amnesia [ Show all ]
Length	532
Amino acid sequence	MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08912
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79961
ChEMBL	CHEMBL2035
IUPHAR	17
DrugBank	BE0000247, BE0004890

Ligand

Name	Cogentinol
Molecular formula	C21H25NO
IUPAC name	3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
Molecular weight	307.437
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.5
Synonyms	Benzotropine Cogentin (Salt/Mix) KBio1_000523 Lopac0_000194 NINDS_000523 Spectrum2_000106 3-diphenylmethoxytropane AC1Q3ZKJ CAS_132-17-2 CTK5E8002 KBio2_005614 NCGC00162087-01 Oprea1_754774 Spectrum5_000884 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, endo- AKOS005661487 BDBM86698 CHEMBL116590 GIJXKZJWITVLHI-UHFFFAOYSA-N KBioSS_000478 NCI60_003960 SCHEMBL35389 Tropine benzohydryl ether 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane Benztropinum Cogentine KBio2_000478 MCULE-5276546081 NK-02 Spectrum3_000316 3.alpha.-(Diphenylmethoxy)-1.alpha.H,5.alpha.H-tropane AC1Q57ZM CCG-204289 DivK1c_000523 KBio3_001412 NCGC00162087-02 Pms Benztropine Spectrum_000078 1.alpha.H,5.alpha.H-Tropane, 3.alpha.-(diphenylmethoxy)- 8-Azabicyclo[3.2.1]octane,3-(diphenylmethoxy)-8-methyl-, hydrobromide (1:1) Apo-Benztropine Benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether # Cobrentin IDI1_000523 L000767 NCIOpen2_008292 SPBio_000092 3-diphenylmethoxy-8-methyl-8-azabicyclo[3.2.1]octane AC1L1DGX BSPBio_001912 KBio2_003046 MolPort-008-334-950 NSC_2344 Spectrum4_000251 (1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, (3-endo)- Akitan CHEBI:94353 EN300-51100 KBioGR_000682 NCGC00162087-03 SBI-0050182.P004 STK931885 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane 80677-48-1 BBL033607 [ Show all ]
Inchi Key	GIJXKZJWITVLHI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3
PubChem CID	2344
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86698
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.8 nM	PMID1346637	PDSP,BindingDB

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