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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Bos taurus (Bovine)
Gene	DRD1
Synonym	Dopamine D1 receptor
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	Q95136
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2967
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Cogentinol
Molecular formula	C21H25NO
IUPAC name	3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
Molecular weight	307.437
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.5
Synonyms	DivK1c_000523 KBio3_001412 NCGC00162087-02 Pms Benztropine Spectrum_000078 1.alpha.H,5.alpha.H-Tropane, 3.alpha.-(diphenylmethoxy)- 8-Azabicyclo[3.2.1]octane,3-(diphenylmethoxy)-8-methyl-, hydrobromide (1:1) Apo-Benztropine CCG-204289 IDI1_000523 L000767 NCIOpen2_008292 SPBio_000092 3-diphenylmethoxy-8-methyl-8-azabicyclo[3.2.1]octane AC1L1DGX Benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether # Cobrentin KBio2_003046 MolPort-008-334-950 NSC_2344 Spectrum4_000251 (1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, (3-endo)- Akitan BSPBio_001912 EN300-51100 KBioGR_000682 NCGC00162087-03 SBI-0050182.P004 STK931885 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane 80677-48-1 BBL033607 CHEBI:94353 KBio1_000523 Lopac0_000194 NINDS_000523 Spectrum2_000106 3-diphenylmethoxytropane AC1Q3ZKJ Benzotropine Cogentin (Salt/Mix) CTK5E8002 KBio2_005614 NCGC00162087-01 Oprea1_754774 Spectrum5_000884 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, endo- AKOS005661487 CAS_132-17-2 GIJXKZJWITVLHI-UHFFFAOYSA-N KBioSS_000478 NCI60_003960 SCHEMBL35389 Tropine benzohydryl ether 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane BDBM86698 CHEMBL116590 KBio2_000478 MCULE-5276546081 NK-02 Spectrum3_000316 3.alpha.-(Diphenylmethoxy)-1.alpha.H,5.alpha.H-tropane AC1Q57ZM Benztropinum Cogentine [ Show all ]
Inchi Key	GIJXKZJWITVLHI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3
PubChem CID	2344
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86698
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID995128	BindingDB

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