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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-2 adrenergic receptor
Species	Cavia porcellus (Guinea pig)
Gene	Adrb2
Synonym	Beta-2 adrenoceptor Beta-2 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	418
Amino acid sequence	MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
UniProt	Q8K4Z4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5414
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Salmeterol
Molecular formula	C25H37NO4
IUPAC name	2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
Molecular weight	415.574
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	3.9
Synonyms	GTPL559 HY-14302 1,3-Benzenedimethanol, 4-hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl-, (+-)- MLS001424322 2-hydroxymethyl-4-{1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl}phenol Q-101428 94749-08-3 (xinafoate) Salmeterol [USAN:BAN:INN] AKOS005561914 Serevent BRD-A01320529-001-05-9 Tox21_113584 CHEBI:64064 D0L5YV FT-0600807 HMS2097N12 (+-)-4-Hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedimethanol KS-00000L6B 1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]-2-methylol-phenol NC00444 4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol AC1L1JPX Salmeterolum [Latin] Astmerole SR-01000076139 C07241 CPD000466295 DSSTox_CID_3571 Glaxo Wellcome brand of salmeterol xinafoate GR-33343-X HMS3714N12 1,3-Benzenedimethanol, 4-hydroxy-.alpha.1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]- LS-29869 2-(hydroxymethyl)-4-[1-hydroxy-2-({6-[(4-phenylbutyl)oxy]hexyl}amino)ethyl]phenol NCGC00025247-02 Salmeterol Impurity H (Xinafoate Adduct Impurity) Aeromax SC-67460 BDBM25771 STK629186 CCG-101194 CTK4C0163 DTXSID6023571 HMS2052H13 ( inverted question mark) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol; GR 33343X K590 1,3-Benzenedimethanol, 4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-, (+-)- MolPort-005-933-084 S 2692 AB00513972 Salmeterol [USAN:INN:BAN] AN-6615 SMR000466295 BSPBio_000910 FT-0674509 HMS3268K19 (inverted question mark) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol L000532 136112-01-1 NCGC00015938-03 4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol Salmeterol (USAN/INN) ACM136112011 SAM001247096 BC202639 SR-01000076139-2 CAS-89365-50-4 CS-2815 DSSTox_GSID_23571 GR 33343 X GR-33343X HSDB 7315 1,3-Benzenedimethanol, 4-hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-, (+-)- MLS000759000 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol Prestwick3_000945 89365-50-4 SalMeterol Xinafoate Adduct IMpurity AK173141 SCHEMBL4767 BPBio1_001002 TL80090037 CCG-205176 D05792 Fluticasonepropiponate HMS2090E17 (+-)-4-Hydroxy-alpha'-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-m-xylene-alpha,alpha'-diol KB-146003 1,3-Benzenedimethanol,4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]- MRF-0000468 365S504 SALMATEROL AB00513972-07 Salmeterolum API0004131 SN408D C-21992 CHEMBL1263 DB00938 GIIZNNXWQWCKIB-UHFFFAOYSA-N HMS3394H13 Lopac0_001100 2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol NCGC00025247-01 5-[2-[6-(4-Phenylbutoxy)hexylamino]-1-hydroxyethyl]-2-hydroxybenzenemethanol Salmeterol Fluticasone Propionate Mixture ACMC-1C1VM SC-23297 BCP04199 SR-01000076139-6 CC-34358 CS0057 DSSTox_RID_77087 GR 33343X [ Show all ]
Inchi Key	GIIZNNXWQWCKIB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2
PubChem CID	5152
ChEMBL	CHEMBL1263
IUPHAR	559
BindingDB	25771
DrugBank	DB00938
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	1.0 -	PMID17897826, PMID17498952	ChEMBL
Activity	6.9 hr	PMID17897826	ChEMBL
EC50	2.7 nM	PMID26471092	BindingDB,ChEMBL
EC50	5.0 nM	PMID21696967, PMID21925889	BindingDB
EC50	5.012 nM	PMID21696967, PMID21925889	ChEMBL
EC50	31.62 nM	PMID24813741	ChEMBL
EC50	32.0 nM	PMID24813741	BindingDB
FC	1.0 -	PMID24359185, PMID21696967	ChEMBL
FC	1.1 -	PMID24359185, PMID21696967	ChEMBL
IC50	3.5 nM	PMID20402514, PMID25065493	BindingDB,ChEMBL
Intrinsic activity	0.5 -	PMID24900851	ChEMBL
pA50	7.7 -	PMID24900851	ChEMBL
p[A]50	7.52 -	PMID9836607	ChEMBL
Ratio EC50	1.0 -	PMID21925889	ChEMBL
Ratio EC50	1.1 -	PMID21925889	ChEMBL
TIME	<10.0 hr	PMID25065493	ChEMBL
TIME	<12.0 hr	PMID20402514	ChEMBL
TIME	0.46 hr	PMID24359185, PMID21696967	ChEMBL
TIME	1.5 hr	PMID24900851	ChEMBL
TIME	2.0 hr	PMID20402514, PMID25065493	ChEMBL
TIME	6.9 hr	PMID17498952	ChEMBL

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