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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 7
Species	Rattus norvegicus (Rat)
Gene	Grm7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	915
Amino acid sequence	MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	P35400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3879
IUPHAR	295
DrugBank	N/A

Ligand

Name	CHEMBL596275
Molecular formula	C18H13N3O2
IUPAC name	5-methyl-6-phenyl-3-pyridin-2-yl-[1,2]oxazolo[4,5-c]pyridin-4-one
Molecular weight	303.321
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.3
Synonyms	BDBM50305867 SCHEMBL6069447 5-methyl-6-phenyl-3-(pyridin-2-yl)isoxazolo[4,5-c]pyridin-4(5H)-one
Inchi Key	GIIFHMOHLHHYCT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H13N3O2/c1-21-14(12-7-3-2-4-8-12)11-15-16(18(21)22)17(20-23-15)13-9-5-6-10-19-13/h2-11H,1H3
PubChem CID	23579324
ChEMBL	CHEMBL596275
IUPHAR	N/A
BindingDB	50305867
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1000.0 nM	PMID20005101	BindingDB,ChEMBL

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