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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL80437
Molecular formula	C18H25N3
IUPAC name	N-(2-phenylethyl)-N-propyl-4,5,6,7-tetrahydro-1H-indazol-5-amine
Molecular weight	283.419
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.9
Synonyms	BDBM50017542 Phenethyl-propyl-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-amine
Inchi Key	ANIKEXZTCGXTKJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H25N3/c1-2-11-21(12-10-15-6-4-3-5-7-15)17-8-9-18-16(13-17)14-19-20-18/h3-7,14,17H,2,8-13H2,1H3,(H,19,20)
PubChem CID	44316827
ChEMBL	CHEMBL80437
IUPHAR	N/A
BindingDB	50017542
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	140.0 nM	PMID2571732	BindingDB,ChEMBL

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