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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	MLS000046638
Molecular formula	C21H32N2O3S
IUPAC name	(4-benzylpiperidin-1-yl)-(1-propylsulfonylpiperidin-3-yl)methanone
Molecular weight	392.558
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.1
Synonyms	AC1MME1E CHEMBL1430943 SMR000032649 HMS2157J07 3-[(4-benzylpiperidin-1-yl)carbonyl]-1-(propylsulfonyl)piperidine NCGC00050246-02 BDBM37695 cid_3237289 [4-(phenylmethyl)-1-piperidinyl]-(1-propylsulfonyl-3-piperidinyl)methanone (4-benzylpiperidin-1-yl)-(1-propylsulfonylpiperidin-3-yl)methanone HMS3308J21 REGID_for_CID_3237289 EU-0098038 [4-(phenylmethyl)piperidin-1-yl]-(1-propylsulfonylpiperidin-3-yl)methanone (4-benzylpiperidino)-(1-propylsulfonyl-3-piperidyl)methanone [ Show all ]
Inchi Key	ANDSXDKABIYGPB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H32N2O3S/c1-2-15-27(25,26)23-12-6-9-20(17-23)21(24)22-13-10-19(11-14-22)16-18-7-4-3-5-8-18/h3-5,7-8,19-20H,2,6,9-17H2,1H3
PubChem CID	3237289
ChEMBL	CHEMBL1430943
IUPHAR	N/A
BindingDB	37695
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<40300.0 nM	N/A	BindingDB

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