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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Bombesin receptor subtype-3
Species	Rattus norvegicus (Rat)
Gene	Brs3
Synonym	bb3 BB3 receptor bombesin like receptor 3 bombesin receptor subtype-3 BRS-3
Disease	N/A for non-human GPCRs
Length	399
Amino acid sequence	MSQRQPQSPNQTLISITNDTETSSSAVSNDTTPKGWTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCAKAGGIWIMAMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLSKTFQKHFKAQLCCFKAEQPEPPLGDTPLNNLTVMGRVPATGSAHVSEISVTLFSGSTAKKGEDKV
UniProt	Q8K418
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075111
IUPHAR	40
DrugBank	N/A

Ligand

Name	CHEMBL1098185
Molecular formula	C22H28N6
IUPAC name	7-benzyl-5-N-cyclohexyl-2,6,8,9-tetrahydropyrazolo[3,4-c][2,7]naphthyridine-1,5-diamine
Molecular weight	376.508
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	4.0
Synonyms	BDBM50317470 MCULE-2396550014 ZINC20100317 7-benzyl-N~5~-cyclohexyl-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-1,5-diamine MolPort-006-382-464 AKOS005434930 STK354826 7-benzyl-N5-cyclohexyl-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-1,5-diamine [ Show all ]
Inchi Key	ANCYCLDLQNJWMK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H28N6/c23-20-19-17-11-12-28(13-15-7-3-1-4-8-15)14-18(17)21(25-22(19)27-26-20)24-16-9-5-2-6-10-16/h1,3-4,7-8,16H,2,5-6,9-14H2,(H4,23,24,25,26,27)
PubChem CID	25249151
ChEMBL	CHEMBL1098185
IUPHAR	N/A
BindingDB	50317470
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	50.0 %	PMID20371178	ChEMBL
EC50	10000.0 nM	PMID20371178	BindingDB,ChEMBL

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