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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	CHEMBL123844
Molecular formula	C27H22O3
IUPAC name	2-[2-[3-(2-phenylmethoxyphenyl)phenyl]phenyl]acetic acid
Molecular weight	394.47
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.3
Synonyms	2''-(Benzyloxy)-1,1':3',1''-terbenzene-2-acetic acid (2''''-Benzyloxy-[1,1'';3'',1'''']terphenyl-2-yl)-acetic acid BDBM50134520
Inchi Key	AMSJJJTTZPVHKS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H22O3/c28-27(29)18-23-11-4-5-14-24(23)21-12-8-13-22(17-21)25-15-6-7-16-26(25)30-19-20-9-2-1-3-10-20/h1-17H,18-19H2,(H,28,29)
PubChem CID	44349531
ChEMBL	CHEMBL123844
IUPHAR	N/A
BindingDB	50134520
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3600.0 nM	PMID14552786	BindingDB,ChEMBL

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