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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	CHEMBL1949969
Molecular formula	C23H27ClN4O2S
IUPAC name	N-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]quinoline-7-sulfonamide
Molecular weight	459.005
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.1
Synonyms	CHEMBL1962400 BDBM50364845
Inchi Key	AMHUPDQQMWOFLY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H27ClN4O2S/c24-20-6-8-21(9-7-20)28-16-14-27(15-17-28)13-2-1-12-26-31(29,30)22-10-5-19-4-3-11-25-23(19)18-22/h3-11,18,26H,1-2,12-17H2
PubChem CID	57396855
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50364845
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	868.0 nM	PMID22277589	BindingDB

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