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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	CHEMBL223700
Molecular formula	C12H8F2O4
IUPAC name	5-(3,5-difluorophenyl)-5-methyl-4-oxofuran-2-carboxylic acid
Molecular weight	254.189
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.9
Synonyms	BDBM50208126 SCHEMBL3099783 5-(3,5-difluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid
Inchi Key	ALXBEPHGSHCMBN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H8F2O4/c1-12(6-2-7(13)4-8(14)3-6)10(15)5-9(18-12)11(16)17/h2-5H,1H3,(H,16,17)
PubChem CID	11817645
ChEMBL	CHEMBL223700
IUPHAR	N/A
BindingDB	50208126
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	33000.0 nM	PMID17358052	BindingDB,ChEMBL

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