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Name | Thyrotropin-releasing hormone receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Trhr |
Synonym | Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor |
Disease | N/A for non-human GPCRs |
Length | 412 |
Amino acid sequence | MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI |
UniProt | Q01717 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4553 |
IUPHAR | 363 |
DrugBank | N/A |
Name | CHEMBL370700 |
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Molecular formula | C19H25N6O5+ |
IUPAC name | 1-[3-(2-carbamoylpyrrolidin-1-yl)-3-oxo-2-[(5-oxopyrrolidine-2-carbonyl)amino]propyl]pyridin-1-ium-3-carboxamide |
Molecular weight | 417.446 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 4 |
XlogP | -3.0 |
Synonyms | 3-carbamoyl-1-{3-(2-carbamoyl-pyrrolidin-1-yl)-3-oxo-2-[(5-oxo-pyrrolidine-2-carbonyl)-amino]-propyl}-pyridinium; Trifluoro-acetate SCHEMBL1371623 1-[2-(5-Oxo-2-pyrrolidinylcarbonylamino)-3-oxo-3-[2-(aminocarbonyl)pyrrolizino]propyl]-3-(aminocarbonyl)pyridinium BDBM50156181 |
Inchi Key | FSAYHTLBOLVRDW-UHFFFAOYSA-O |
Inchi ID | InChI=1S/C19H24N6O5/c20-16(27)11-3-1-7-24(9-11)10-13(23-18(29)12-5-6-15(26)22-12)19(30)25-8-2-4-14(25)17(21)28/h1,3,7,9,12-14H,2,4-6,8,10H2,(H5-,20,21,22,23,26,27,28,29)/p+1 |
PubChem CID | 10387244 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50156181 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <10000.0 nM | PMID15537357 | BindingDB |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417