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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	CHEMBL334989
Molecular formula	C19H25NO
IUPAC name	3-(4-methylphenyl)-N-(3-phenoxypropyl)propan-1-amine
Molecular weight	283.415
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.5
Synonyms	(3-Phenoxy-propyl)-(3-p-tolyl-propyl)-amine BDBM50061331 3-Phenoxy-N-(3-p-tolylpropyl)-1-propanamine
Inchi Key	ALJVVUIFWXGXTR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25NO/c1-17-10-12-18(13-11-17)7-5-14-20-15-6-16-21-19-8-3-2-4-9-19/h2-4,8-13,20H,5-7,14-16H2,1H3
PubChem CID	9948965
ChEMBL	CHEMBL334989
IUPHAR	N/A
BindingDB	50061331
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	347.0 nM	PMID9406594	ChEMBL
Ki	347.0 nM	PMID9406594	BindingDB

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