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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	2-CHLORO-1-(4-CHLORO-3-THIENYL)-ETHANONE
Molecular formula	C6H4Cl2OS
IUPAC name	2-chloro-1-(4-chlorothiophen-3-yl)ethanone
Molecular weight	195.057
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	2.5
Synonyms	2-chloro-1-(4-chlorothiophen-3-yl)ethan-1-one DTXSID20424885 ZINC13528241 AC1O6Z7Y CHEMBL343821 2-chloro-1-(4-chlorothiophen-3-yl)ethanone KB-283641 BDBM7855 2-Chloro-1-(4-chloro-3-thienyl)ethanone Chloromethyl Thienyl Ketone deriv. 3 SCHEMBL6790251 342402-24-8 [ Show all ]
Inchi Key	FODULVJWIHXFJX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H4Cl2OS/c7-1-6(9)4-2-10-3-5(4)8/h2-3H,1H2
PubChem CID	6539167
ChEMBL	CHEMBL343821
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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