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GPCR

NameP2Y purinoceptor 1
SpeciesMeleagris gallopavo (Wild turkey)
GeneP2RY1
Synonym6H1 orphan receptor
ADP receptor
P2Y1
Purinergic receptor
DiseaseN/A for non-human GPCRs
Length362
Amino acid sequenceMTEALISAALNGTQPELLAGGWAAGNASTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL
UniProtP49652
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5720
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL610985
Molecular formulaC18H21N6O9PS
IUPAC name[(2R,3S,4R)-5-[6-amino-2-[2-(4-nitrophenyl)ethylsulfanyl]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Molecular weight528.433
Hydrogen bond acceptor14
Hydrogen bond donor5
XlogP-0.9
SynonymsN/A
Inchi KeyFNLQRMZCHRPOBQ-IKYDMHQPSA-N
Inchi IDInChI=1S/C18H21N6O9PS/c19-15-12-16(22-18(21-15)35-6-5-9-1-3-10(4-2-9)24(27)28)23(8-20-12)17-14(26)13(25)11(33-17)7-32-34(29,30)31/h1-4,8,11,13-14,17,25-26H,5-7H2,(H2,19,21,22)(H2,29,30,31)/t11-,13-,14-,17?/m1/s1
PubChem CID46876119
ChEMBLCHEMBL610985
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC503000.0 nMPMID10479295ChEMBL

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