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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2037467
Molecular formula	C11H11NO2S
IUPAC name	3-cyclopropyl-6-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Molecular weight	221.274
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.0
Synonyms	BDBM50385241
Inchi Key	FMVDSUJWEDWDQD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H11NO2S/c1-5-8(11(13)14)12-9-7(6-2-3-6)4-15-10(5)9/h4,6,12H,2-3H2,1H3,(H,13,14)
PubChem CID	70681839
ChEMBL	CHEMBL2037467
IUPHAR	N/A
BindingDB	50385241
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	8370.0 nM	PMID22572579	BindingDB,ChEMBL
EC50	119000.0 nM	PMID22572579	BindingDB,ChEMBL
Efficacy	35.0 %	PMID22572579	ChEMBL
Efficacy	228.0 %	PMID22572579	ChEMBL

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