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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Rattus norvegicus (Rat)
Gene	Gcgr
Synonym	GGR GL-R glucagon receptor GR
Disease	N/A for non-human GPCRs
Length	485
Amino acid sequence	MLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProt	P30082
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4720
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL557974
Molecular formula	C22H24Cl2N4
IUPAC name	N'-[6,7-dichloro-3-[(E)-2-phenylethenyl]quinoxalin-2-yl]-N,N,N'-trimethylpropane-1,3-diamine
Molecular weight	415.362
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.6
Synonyms	BDBM50280717 N1-[6,7-DICHLORO-3-(2-PHENYLETHENYL)-2-QUINOXALINYL]-N1,N3,N3-TRIMETHYL-1,3-PROPANEDIAMINE CP-99-711 149366-39-2 N-(6,7-Dichloro-3-styrylquinoalin-2-yl)-N,N,N-trimethylpropane-1,3-diamine CHEMBL1196711 SCHEMBL2645268 CP-99711 N-[6,7-Dichloro-3-((E)-styryl)-quinoxalin-2-yl]-N,N'',N''-trimethyl-propane-1,3-diamine; hydrochloride ZINC3779708 KB-56077 [ Show all ]
Inchi Key	FJJZLLDDYQTGGH-ZHACJKMWSA-N
Inchi ID	InChI=1S/C22H24Cl2N4/c1-27(2)12-7-13-28(3)22-19(11-10-16-8-5-4-6-9-16)25-20-14-17(23)18(24)15-21(20)26-22/h4-6,8-11,14-15H,7,12-13H2,1-3H3/b11-10+
PubChem CID	9844728
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50280717
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4000.0 nM	N/A	BindingDB

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