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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	CHEMBL1940417
Molecular formula	C17H21FN4O
IUPAC name	2-[4-[3-(4-fluorophenoxy)propyl]piperazin-1-yl]pyrimidine
Molecular weight	316.38
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.6
Synonyms	AKOS017132333 BDBM50362862
Inchi Key	FGFQEEFTBWHCLW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H21FN4O/c18-15-3-5-16(6-4-15)23-14-2-9-21-10-12-22(13-11-21)17-19-7-1-8-20-17/h1,3-8H,2,9-14H2
PubChem CID	57396484
ChEMBL	CHEMBL1940417
IUPHAR	N/A
BindingDB	50362862
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID22245230	BindingDB,ChEMBL

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