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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392183
Molecular formula	C17H11BrN2O6
IUPAC name	6-bromo-8-[(6-methoxypyridine-3-carbonyl)amino]-4-oxochromene-2-carboxylic acid
Molecular weight	419.187
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	2.0
Synonyms	BDBM50435998
Inchi Key	FFRLOXKAKNBOMY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H11BrN2O6/c1-25-14-3-2-8(7-19-14)16(22)20-11-5-9(18)4-10-12(21)6-13(17(23)24)26-15(10)11/h2-7H,1H3,(H,20,22)(H,23,24)
PubChem CID	71733940
ChEMBL	CHEMBL2392183
IUPHAR	N/A
BindingDB	50435998
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	30.0 nM	PMID23713606	BindingDB
EC50	30.2 nM	PMID23713606	ChEMBL
EC50	30.5 nM	PMID23713606	ChEMBL
EC50	31.0 nM	PMID23713606	BindingDB
Emax	117.0 %	PMID23713606	ChEMBL
Ki	25.7 nM	PMID23888932	ChEMBL
Ki	26.0 nM	PMID23888932	BindingDB

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