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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL51558
Molecular formula	C20H30N4O3
IUPAC name	1-[5-ethyl-2-hydroxy-4-[7-methyl-7-(2H-tetrazol-5-yl)octoxy]phenyl]ethanone
Molecular weight	374.485
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	5.1
Synonyms	4'-[7-Methyl-7-(1H-tetrazol-5-yl)octyloxy]-5'-ethyl-2'-hydroxyacetophenone
Inchi Key	FFBXXZSZNZOOBV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H30N4O3/c1-5-15-12-16(14(2)25)17(26)13-18(15)27-11-9-7-6-8-10-20(3,4)19-21-23-24-22-19/h12-13,26H,5-11H2,1-4H3,(H,21,22,23,24)
PubChem CID	15747305
ChEMBL	CHEMBL51558
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	67.0 %	PMID1316967	ChEMBL

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